Methamphetamine Use in HIV-infected Individuals Affects T-cell Function and Viral Outcome during Suppressive Antiretroviral Therapy

We investigated the associations between methamphetamine (meth) use, immune function and the dynamics of HIV and cytomegalovirus [CMV] in the blood and genital tract of HIV-infected ART-suppressed subjects. Self-reported meth use was associated with increased CD4 + and CD8 + T-cell proliferation (Ki...

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Bibliographic Details
Published in:Scientific reports 2015-08, Vol.5 (1), p.13179-13179, Article 13179
Main Authors: Massanella, Marta, Gianella, Sara, Schrier, Rachel, Dan, Jennifer M., Pérez-Santiago, Josué, Oliveira, Michelli F., Richman, Douglas D., Little, Susan J., Benson, Constance A., Daar, Eric S., Dube, Michael P., Haubrich, Richard H., Smith, Davey M., Morris, Sheldon R.
Format: Article
Language:English
Subjects:
692/420/2780
692/499
Adult
Antiretroviral agents
Antiretroviral drugs
Antiretroviral Therapy, Highly Active
Blood
Case-Control Studies
Cell Proliferation
Cytomegalovirus
DNA, Viral - analysis
HIV Antigens - immunology
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
Humanities and Social Sciences
Humans
Immune response
Immune system
Immunology
Infections
Lymphocytes
Lymphocytes T
Methamphetamine
Methamphetamine - therapeutic use
Middle Aged
Monocytes - immunology
multidisciplinary
Pathogens
Receptors, CCR5 - metabolism
Science
T cell receptors
T-Lymphocytes - immunology
Treatment Outcome
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Summary:We investigated the associations between methamphetamine (meth) use, immune function and the dynamics of HIV and cytomegalovirus [CMV] in the blood and genital tract of HIV-infected ART-suppressed subjects. Self-reported meth use was associated with increased CD4 + and CD8 + T-cell proliferation (Ki67 + , p  
ISSN:2045-2322
2045-2322
DOI:10.1038/srep13179