Brain ventricular dimensions and relationship to outcome in adult patients with bacterial meningitis

Experimental studies suggest that changes in brain ventricle size are key events in bacterial meningitis. This study investigated the relationship between ventricle size, clinical condition and risk of poor outcome in patients with bacterial meningitis. Adult patients diagnosed with bacterial mening...

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Bibliographic Details
Published in:BMC infectious diseases 2015-08, Vol.15 (1), p.367-367, Article 367
Main Authors: Sporrborn, Janni L, Knudsen, Gertrud B, Sølling, Mette, Seierøe, Karina, Farre, Annette, Lindhardt, Bjarne Ø, Benfield, Thomas, Brandt, Christian T
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Brain - diagnostic imaging
Cerebral Ventricles - pathology
CT imaging
Denmark
Female
Humans
Male
Meningitis, Bacterial - diagnosis
Meningitis, Bacterial - diagnostic imaging
Meningitis, Bacterial - mortality
Middle Aged
Multivariate Analysis
Retrospective Studies
Risk Factors
Survival Analysis
Tomography, X-Ray Computed
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Summary:Experimental studies suggest that changes in brain ventricle size are key events in bacterial meningitis. This study investigated the relationship between ventricle size, clinical condition and risk of poor outcome in patients with bacterial meningitis. Adult patients diagnosed with bacterial meningitis admitted to two departments of infectious diseases from 2003 through 2010 were identified. Clinical and biochemical data as well as cerebral computed tomographic images were collected. The size of the brain ventricles were presented as a Ventricle to Brain Ratio (VBR). Normal range of VBR was defined from an age matched control group. A multivariate analysis was performed to identify predictors of 30-day mortality. One hundred and seven patients were included. Eighty-one patients had a CT scan at the time of diagnosis. VBR was identified as an independent risk factor of 30-day mortality, Mortality Rate Ratio: 6.03 (95 % confidence interval: 1.61-22.64, p = 0.008) for highest versus lowest tertile. A VBR deviating more than 2 standard deviations from the normal range was associated with increased mortality. Brain ventricles are commonly subject to marked changes in size as a consequence of meningitis. Increased brain ventricle size in the acute phase of bacterial meningitis was associated with increased mortality.
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-015-1097-3