Inflammatory and vascular markers and olfactory impairment in older adults

the incidence of olfactory impairment increases sharply in the eighth and ninth decades of life but the aetiology of age-related olfactory decline is not well understood. Inflammation and atherosclerosis are associated with many age-related conditions and atherosclerosis has been associated with olf...

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Bibliographic Details
Published in:Age and ageing 2015-09, Vol.44 (5), p.878-882
Main Authors: Schubert, Carla R, Cruickshanks, Karen J, Fischer, Mary E, Klein, Barbara E K, Klein, Ronald, Pinto, A Alex
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
Aging
Atherosclerosis
Biomarkers
Biomarkers - blood
C-Reactive Protein - analysis
Carotid Arteries - diagnostic imaging
Carotid Arteries - pathology
Carotid Artery Diseases - diagnosis
Carotid Artery Diseases - epidemiology
Carotid Intima-Media Thickness
Epidemiology
Female
Health aspects
Humans
Incidence
Inflammation - blood
Inflammation - diagnosis
Inflammation - epidemiology
Inflammation Mediators - blood
Interleukin-6 - blood
Longitudinal Studies
Male
Middle Aged
Older people
Olfaction Disorders - diagnosis
Olfaction Disorders - epidemiology
Olfaction Disorders - physiopathology
Plaque, Atherosclerotic
Proportional Hazards Models
Risk Factors
Short Reports
Smell
Tumor Necrosis Factor-alpha - blood
Wisconsin - epidemiology
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Summary:the incidence of olfactory impairment increases sharply in the eighth and ninth decades of life but the aetiology of age-related olfactory decline is not well understood. Inflammation and atherosclerosis are associated with many age-related conditions and atherosclerosis has been associated with olfactory decline in middle-aged adults. to determine if inflammatory markers and atherosclerosis are associated with the development of olfactory impairment in older adults. longitudinal, population-based study. a total of 1,611 participants, aged 53-97 years in the Epidemiology of Hearing Loss Study without olfactory impairment at the 1998-2000 examination and with follow-up at a subsequent examination 5 and/or 10 years later. the San Diego Odor Identification Test was used to measure olfaction. High sensitivity C-reactive protein, interleukin-6 and tumour necrosis factor-α were measured in serum and carotid ultrasound images were obtained for the measurement of carotid intima media thickness (IMT) and plaque assessment. Medical history, behavioural and lifestyle information were obtained by interview. inflammatory markers, IMT and plaque were not associated with the 10-year cumulative incidence of olfactory impairment in adjusted Cox proportional hazard models. Among those
ISSN:0002-0729
1468-2834
DOI:10.1093/ageing/afv075