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Inflammatory and vascular markers and olfactory impairment in older adults
the incidence of olfactory impairment increases sharply in the eighth and ninth decades of life but the aetiology of age-related olfactory decline is not well understood. Inflammation and atherosclerosis are associated with many age-related conditions and atherosclerosis has been associated with olf...
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| Published in: | Age and ageing 2015-09, Vol.44 (5), p.878-882 |
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| Main Authors: | , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c552t-e211c461922eb9fc9831cd07c434281de9a2be4fdd6a9dc24dfd5135c2449e73 |
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| cites | cdi_FETCH-LOGICAL-c552t-e211c461922eb9fc9831cd07c434281de9a2be4fdd6a9dc24dfd5135c2449e73 |
| container_end_page | 882 |
| container_issue | 5 |
| container_start_page | 878 |
| container_title | Age and ageing |
| container_volume | 44 |
| creator | Schubert, Carla R Cruickshanks, Karen J Fischer, Mary E Klein, Barbara E K Klein, Ronald Pinto, A Alex |
| description | the incidence of olfactory impairment increases sharply in the eighth and ninth decades of life but the aetiology of age-related olfactory decline is not well understood. Inflammation and atherosclerosis are associated with many age-related conditions and atherosclerosis has been associated with olfactory decline in middle-aged adults.
to determine if inflammatory markers and atherosclerosis are associated with the development of olfactory impairment in older adults.
longitudinal, population-based study.
a total of 1,611 participants, aged 53-97 years in the Epidemiology of Hearing Loss Study without olfactory impairment at the 1998-2000 examination and with follow-up at a subsequent examination 5 and/or 10 years later.
the San Diego Odor Identification Test was used to measure olfaction. High sensitivity C-reactive protein, interleukin-6 and tumour necrosis factor-α were measured in serum and carotid ultrasound images were obtained for the measurement of carotid intima media thickness (IMT) and plaque assessment. Medical history, behavioural and lifestyle information were obtained by interview.
inflammatory markers, IMT and plaque were not associated with the 10-year cumulative incidence of olfactory impairment in adjusted Cox proportional hazard models. Among those |
| doi_str_mv | 10.1093/ageing/afv075 |
| format | article |
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to determine if inflammatory markers and atherosclerosis are associated with the development of olfactory impairment in older adults.
longitudinal, population-based study.
a total of 1,611 participants, aged 53-97 years in the Epidemiology of Hearing Loss Study without olfactory impairment at the 1998-2000 examination and with follow-up at a subsequent examination 5 and/or 10 years later.
the San Diego Odor Identification Test was used to measure olfaction. High sensitivity C-reactive protein, interleukin-6 and tumour necrosis factor-α were measured in serum and carotid ultrasound images were obtained for the measurement of carotid intima media thickness (IMT) and plaque assessment. Medical history, behavioural and lifestyle information were obtained by interview.
inflammatory markers, IMT and plaque were not associated with the 10-year cumulative incidence of olfactory impairment in adjusted Cox proportional hazard models. Among those <60 years, the mean IMT [hazard ratio (HR) = 4.35, 95% confidence interval (CI) = 1.69-11.21, tertile 3 versus tertile 1] and the number of sites with plaque (HR = 1.56, 95% CI = 1.17-2.08, per site) were associated with an increased risk of developing an olfactory impairment at follow-up.
subclinical atherosclerosis at a younger age may be a risk factor for the development of olfactory impairment.</description><identifier>ISSN: 0002-0729</identifier><identifier>EISSN: 1468-2834</identifier><identifier>DOI: 10.1093/ageing/afv075</identifier><identifier>PMID: 26082178</identifier><identifier>CODEN: AANGAH</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Aging ; Atherosclerosis ; Biomarkers ; Biomarkers - blood ; C-Reactive Protein - analysis ; Carotid Arteries - diagnostic imaging ; Carotid Arteries - pathology ; Carotid Artery Diseases - diagnosis ; Carotid Artery Diseases - epidemiology ; Carotid Intima-Media Thickness ; Epidemiology ; Female ; Health aspects ; Humans ; Incidence ; Inflammation - blood ; Inflammation - diagnosis ; Inflammation - epidemiology ; Inflammation Mediators - blood ; Interleukin-6 - blood ; Longitudinal Studies ; Male ; Middle Aged ; Older people ; Olfaction Disorders - diagnosis ; Olfaction Disorders - epidemiology ; Olfaction Disorders - physiopathology ; Plaque, Atherosclerotic ; Proportional Hazards Models ; Risk Factors ; Short Reports ; Smell ; Tumor Necrosis Factor-alpha - blood ; Wisconsin - epidemiology</subject><ispartof>Age and ageing, 2015-09, Vol.44 (5), p.878-882</ispartof><rights>The Author 2015. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</rights><rights>Copyright Oxford Publishing Limited(England) Sep 2015</rights><rights>The Author 2015. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-e211c461922eb9fc9831cd07c434281de9a2be4fdd6a9dc24dfd5135c2449e73</citedby><cites>FETCH-LOGICAL-c552t-e211c461922eb9fc9831cd07c434281de9a2be4fdd6a9dc24dfd5135c2449e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925,30999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26082178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schubert, Carla R</creatorcontrib><creatorcontrib>Cruickshanks, Karen J</creatorcontrib><creatorcontrib>Fischer, Mary E</creatorcontrib><creatorcontrib>Klein, Barbara E K</creatorcontrib><creatorcontrib>Klein, Ronald</creatorcontrib><creatorcontrib>Pinto, A Alex</creatorcontrib><title>Inflammatory and vascular markers and olfactory impairment in older adults</title><title>Age and ageing</title><addtitle>Age Ageing</addtitle><description>the incidence of olfactory impairment increases sharply in the eighth and ninth decades of life but the aetiology of age-related olfactory decline is not well understood. Inflammation and atherosclerosis are associated with many age-related conditions and atherosclerosis has been associated with olfactory decline in middle-aged adults.
to determine if inflammatory markers and atherosclerosis are associated with the development of olfactory impairment in older adults.
longitudinal, population-based study.
a total of 1,611 participants, aged 53-97 years in the Epidemiology of Hearing Loss Study without olfactory impairment at the 1998-2000 examination and with follow-up at a subsequent examination 5 and/or 10 years later.
the San Diego Odor Identification Test was used to measure olfaction. High sensitivity C-reactive protein, interleukin-6 and tumour necrosis factor-α were measured in serum and carotid ultrasound images were obtained for the measurement of carotid intima media thickness (IMT) and plaque assessment. Medical history, behavioural and lifestyle information were obtained by interview.
inflammatory markers, IMT and plaque were not associated with the 10-year cumulative incidence of olfactory impairment in adjusted Cox proportional hazard models. Among those <60 years, the mean IMT [hazard ratio (HR) = 4.35, 95% confidence interval (CI) = 1.69-11.21, tertile 3 versus tertile 1] and the number of sites with plaque (HR = 1.56, 95% CI = 1.17-2.08, per site) were associated with an increased risk of developing an olfactory impairment at follow-up.
subclinical atherosclerosis at a younger age may be a risk factor for the development of olfactory impairment.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Atherosclerosis</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Arteries - pathology</subject><subject>Carotid Artery Diseases - diagnosis</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Inflammation - blood</subject><subject>Inflammation - diagnosis</subject><subject>Inflammation - epidemiology</subject><subject>Inflammation Mediators - blood</subject><subject>Interleukin-6 - blood</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Olfaction Disorders - diagnosis</subject><subject>Olfaction Disorders - epidemiology</subject><subject>Olfaction Disorders - physiopathology</subject><subject>Plaque, Atherosclerotic</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><subject>Short Reports</subject><subject>Smell</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Wisconsin - epidemiology</subject><issn>0002-0729</issn><issn>1468-2834</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqNkUtv1DAUhS0EotPCki2KxIZNqJ9JvEGqRlCKKnXTvXXHvgkpjj3Yyaj993hmSnmsWNm-_nR8fA4hbxj9wKgW5zDgGIZz6He0Vc_Iismmq3kn5HOyopTymrZcn5DTnO_KkSnGX5IT3tCOs7Zbka9XofcwTTDH9FBBcNUOsl08pGqC9B1TPgyj78EekHHawpgmDHM1hjJ3mCpwi5_zK_KiB5_x9eN6Rm4_f7pdf6mvby6v1hfXtVWKzzVyxqxsmOYcN7q3uhPMOtpaKSTvmEMNfIOyd64B7SyXrneKCVV2UmMrzsjHo-x22UzobHGSwJttGovhBxNhNH_fhPGbGeLOSCVbzZsi8P5RIMUfC-bZTGO26D0EjEs2rFVCKtUx-h9oCV1Jqfa23v2D3sUlhRLEnupUy-Th7fpIDeDRjMHGMOP9bKP3OKApOa1vzIUUvGm0lPQ3b1PMOWH_9E9Gzb5_c-zfHPsv_Ns_w3mifxUufgKtWa1y</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Schubert, Carla R</creator><creator>Cruickshanks, Karen J</creator><creator>Fischer, Mary E</creator><creator>Klein, Barbara E K</creator><creator>Klein, Ronald</creator><creator>Pinto, A Alex</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7QR</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20150901</creationdate><title>Inflammatory and vascular markers and olfactory impairment in older adults</title><author>Schubert, Carla R ; Cruickshanks, Karen J ; Fischer, Mary E ; Klein, Barbara E K ; Klein, Ronald ; Pinto, A Alex</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-e211c461922eb9fc9831cd07c434281de9a2be4fdd6a9dc24dfd5135c2449e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Atherosclerosis</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Arteries - pathology</topic><topic>Carotid Artery Diseases - diagnosis</topic><topic>Carotid Artery Diseases - epidemiology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Incidence</topic><topic>Inflammation - blood</topic><topic>Inflammation - diagnosis</topic><topic>Inflammation - epidemiology</topic><topic>Inflammation Mediators - blood</topic><topic>Interleukin-6 - blood</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Olfaction Disorders - diagnosis</topic><topic>Olfaction Disorders - epidemiology</topic><topic>Olfaction Disorders - physiopathology</topic><topic>Plaque, Atherosclerotic</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><topic>Short Reports</topic><topic>Smell</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Wisconsin - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schubert, Carla R</creatorcontrib><creatorcontrib>Cruickshanks, Karen J</creatorcontrib><creatorcontrib>Fischer, Mary E</creatorcontrib><creatorcontrib>Klein, Barbara E K</creatorcontrib><creatorcontrib>Klein, Ronald</creatorcontrib><creatorcontrib>Pinto, A Alex</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Chemoreception Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Age and ageing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schubert, Carla R</au><au>Cruickshanks, Karen J</au><au>Fischer, Mary E</au><au>Klein, Barbara E K</au><au>Klein, Ronald</au><au>Pinto, A Alex</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammatory and vascular markers and olfactory impairment in older adults</atitle><jtitle>Age and ageing</jtitle><addtitle>Age Ageing</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>44</volume><issue>5</issue><spage>878</spage><epage>882</epage><pages>878-882</pages><issn>0002-0729</issn><eissn>1468-2834</eissn><coden>AANGAH</coden><abstract>the incidence of olfactory impairment increases sharply in the eighth and ninth decades of life but the aetiology of age-related olfactory decline is not well understood. Inflammation and atherosclerosis are associated with many age-related conditions and atherosclerosis has been associated with olfactory decline in middle-aged adults.
to determine if inflammatory markers and atherosclerosis are associated with the development of olfactory impairment in older adults.
longitudinal, population-based study.
a total of 1,611 participants, aged 53-97 years in the Epidemiology of Hearing Loss Study without olfactory impairment at the 1998-2000 examination and with follow-up at a subsequent examination 5 and/or 10 years later.
the San Diego Odor Identification Test was used to measure olfaction. High sensitivity C-reactive protein, interleukin-6 and tumour necrosis factor-α were measured in serum and carotid ultrasound images were obtained for the measurement of carotid intima media thickness (IMT) and plaque assessment. Medical history, behavioural and lifestyle information were obtained by interview.
inflammatory markers, IMT and plaque were not associated with the 10-year cumulative incidence of olfactory impairment in adjusted Cox proportional hazard models. Among those <60 years, the mean IMT [hazard ratio (HR) = 4.35, 95% confidence interval (CI) = 1.69-11.21, tertile 3 versus tertile 1] and the number of sites with plaque (HR = 1.56, 95% CI = 1.17-2.08, per site) were associated with an increased risk of developing an olfactory impairment at follow-up.
subclinical atherosclerosis at a younger age may be a risk factor for the development of olfactory impairment.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>26082178</pmid><doi>10.1093/ageing/afv075</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Age and ageing, 2015-09, Vol.44 (5), p.878-882 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4547926 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); Oxford Journals Online |
| subjects | Age Factors Aged Aged, 80 and over Aging Atherosclerosis Biomarkers Biomarkers - blood C-Reactive Protein - analysis Carotid Arteries - diagnostic imaging Carotid Arteries - pathology Carotid Artery Diseases - diagnosis Carotid Artery Diseases - epidemiology Carotid Intima-Media Thickness Epidemiology Female Health aspects Humans Incidence Inflammation - blood Inflammation - diagnosis Inflammation - epidemiology Inflammation Mediators - blood Interleukin-6 - blood Longitudinal Studies Male Middle Aged Older people Olfaction Disorders - diagnosis Olfaction Disorders - epidemiology Olfaction Disorders - physiopathology Plaque, Atherosclerotic Proportional Hazards Models Risk Factors Short Reports Smell Tumor Necrosis Factor-alpha - blood Wisconsin - epidemiology |
| title | Inflammatory and vascular markers and olfactory impairment in older adults |
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