Hepatitis A complicated with acute renal failure and high hepatocyte growth factor:A case report

A 58-year-old man was admitted to our hospital. Laboratory data showed severe liver injury and that the patient was positive for immunoglobulin M anti-hepatitis A virus(HAV) antibodies. He was also complicated with severe renal dysfunction and had an extremely high level of serum hepatocyte growth f...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2015-08, Vol.21 (32), p.9671-9674
Main Authors: Oe, Shinji, Shibata, Michihiko, Miyagawa, Koichiro, Honma, Yuichi, Hiura, Masaaki, Abe, Shintaro, Harada, Masaru
Format: Article
Language:English
Subjects:
Acute
Acute Kidney Injury - blood
Acute Kidney Injury - diagnosis
Acute Kidney Injury - therapy
Acute Kidney Injury - virology
Biomarkers - blood
Case Report
failure
Hepatitis
Hepatitis A - blood
Hepatitis A - complications
Hepatitis A - diagnosis
Hepatitis A - therapy
Hepatitis A Antibodies - blood
hepatitis
Acute
Hepatocyte Growth Factor - blood
Humans
Immunoglobulin M - blood
Liver Failure, Acute - blood
Liver Failure, Acute - diagnosis
Liver Failure, Acute - therapy
Liver Failure, Acute - virology
Male
Middle Aged
renal
Time Factors
Treatment Outcome
Up-Regulation
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Summary:A 58-year-old man was admitted to our hospital. Laboratory data showed severe liver injury and that the patient was positive for immunoglobulin M anti-hepatitis A virus(HAV) antibodies. He was also complicated with severe renal dysfunction and had an extremely high level of serum hepatocyte growth factor(HGF). Therefore, he was diagnosed with severe acute liver failure with acute renal failure(ARF) caused by HAV infection. Prognosis was expected to be poor because of complications by ARF and high serum HGF. However, liver and renal functions both improved rapidly without intensive treatment, and he was subsequently discharged from our hospital on the 21 st hospital day. Although complication with ARF and high levels of serum HGF are both important factors predicting poor prognosis in acute liver failure patients, the present case achieved a favorable outcome. Endogenous HGF might play an important role as a regenerative effector in injured livers and kidneys.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v21.i32.9671