Left brain cortical activity modulates stress effects on social behavior

When subjected to stress, some individuals develop maladaptive symptoms whereas others retain normal behavior. The medial prefrontal cortex (mPFC) is known to control these adaptive responses to stress. Here, we show that mPFC neurons in the left hemisphere control stress effects on social behavior....

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Bibliographic Details
Published in:Scientific reports 2015-08, Vol.5 (1), p.13342-13342, Article 13342
Main Authors: Lee, Eunee, Hong, Jiso, Park, Young-Gyun, Chae, Sujin, Kim, Yong, Kim, Daesoo
Format: Article
Language:English
Subjects:
631/378/1689/1414
631/378/1831
Adaptation, Physiological
Animals
Anxiety
Anxiety disorders
Avoidance Learning
Behavior
Behavior, Animal
Dominance, Cerebral
Hemispheric laterality
Humanities and Social Sciences
Male
Mental depression
Mice
Mice, Inbred C57BL
Mood
multidisciplinary
Nerve Net - physiopathology
Neurons
Photoactivation
Photoinhibition
Post traumatic stress disorder
Prefrontal cortex
Prefrontal Cortex - physiopathology
Science
Social Behavior
Social Behavior Disorders - complications
Social Behavior Disorders - physiopathology
Social interaction
Social interactions
Stress, Psychological - complications
Stress, Psychological - physiopathology
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Summary:When subjected to stress, some individuals develop maladaptive symptoms whereas others retain normal behavior. The medial prefrontal cortex (mPFC) is known to control these adaptive responses to stress. Here, we show that mPFC neurons in the left hemisphere control stress effects on social behavior. Mice made socially avoidant by the stress of chronic social defeats showed depressed neural activity in the left mPFC. Photoactivation of these neurons reversed social avoidance and restored social activity. Despite social defeats, resilient mice with normal sociability showed normal firing rates in the left mPFC; however, photoinhibition of these neurons induced social avoidance. The same photomodulation administered to the right mPFC caused no significant effects. These results explain how stressed individuals develop maladaptive behaviors through left cortical depression, as reported in mood and anxiety disorders.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep13342