Neuroprotective effect of Spirulina fusiform and amantadine in the 6-OHDA induced Parkinsonism in rats

• Published in: BMC complementary and alternative medicine 2015-08, Vol.15 (1), p.296, Article 296
• Main Authors: Chattopadhyaya, I, Gupta, Sumeet, Mohammed, Asad, Mushtaq, N, Chauhan, S, Ghosh, Saikat, Ghosh, Saikant
• Format: Article
• Language: English
• Subjects: Amantadine - pharmacology; Animals; Antioxidants; Dietary Supplements; Drug therapy; Health aspects; Neuroprotective Agents - pharmacology; Oxidopamine; Parkinson's disease; Parkinsonian Disorders - chemically induced; Parkinsonian Disorders - physiopathology; Rats; Spirulina
• ISSN: 1472-6882; 1472-6882
• DOI: 10.1186/s12906-015-0815-0

Multi-factorial etiology exists in pathophysiology of neurodegenerative diseases. The imbalance of anti-oxidant enzymes and dopamine level leads to Parkinsonism. The objective of this study was to assess the protective effect of Spirulina fusiform alone and in combination with amantadine against Parkinsonism effect in 6-hydroxydopamine (6-OHDA) induced rat model. S. fusiform was administered in different groups (500 mg/kg, once daily and twice daily) and a combination of spirulina (500 mg/kg, once daily) with amantadine (20 mg/kg once daily) for 30 days before and 14 days after a single injection of 6-OHDA into the dorsal striatum. Post lesion produced rotational behavior which was measured at two week intervals (37th and 44th day). Locomotors activity was also done at 44th and muscle coordination at 48th day. Dorsal striatum was isolated from rat brain for evaluating the antioxidant assays and dopamine content at 49th day. Both the body rotations (ipsilateral and contralateral) were found to have a statistically significant (p