Iron‐induced myocardial injury: an alarming side effect of superparamagnetic iron oxide nanoparticles

[...]iron oxide particles stabilized with coatings, such as dextran or citric acid, induced toxic effects on the behaviour and function of endothelial cells and activated the expression of genes related to oxidative stress . [...]acute myocardial ischaemia (specifically after reperfusion) can genera...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular and molecular medicine 2015-08, Vol.19 (8), p.2032-2035
Main Authors: Shen, Yunli, Huang, Zheyong, Liu, Xuebo, Qian, Juying, Xu, Jianfeng, Yang, Xiangdong, Sun, Aijun, Ge, Junbo
Format: Article
Language:English
Subjects:
Acetylcysteine
Animals
Antioxidants
Cardiomyocytes
Cardiovascular disease
Cell death
Cell membranes
Citric acid
Dextran
Dextrans - toxicity
Drug dosages
Endothelial cells
Genes
Heart attacks
Hypotheses
Iron
Iron - toxicity
Iron oxides
Ischemia
Letter to the Editor
Lipid peroxidation
Lipids
Magnetic fields
Magnetite Nanoparticles - toxicity
Models, Biological
Myocardium - pathology
Nanoparticles
Oxidative stress
Rats
Reactive oxygen species
Reperfusion
Stem cells
Toxicity
Vitamin E
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[...]iron oxide particles stabilized with coatings, such as dextran or citric acid, induced toxic effects on the behaviour and function of endothelial cells and activated the expression of genes related to oxidative stress . [...]acute myocardial ischaemia (specifically after reperfusion) can generate ROS via activation of the oxidative stress system and then directly injuring the cell membrane of cardiomyocytes and induce cell death . [...]the efficacy of novel SPION coated with antioxidants (such as N‐Acetylcysteine or Trolox) was investigated in attenuating oxidative stress‐mediated cardiac injury, further validating the SPION's adverse effects and its mechanism.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.12582