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Cough during infancy and subsequent childhood asthma
Summary Objectives Wheezing in infancy has been associated with subsequent asthma, but whether cough similarly influences asthma risk has been little studied. We sought to determine whether prolonged cough and cough without cold in the first year of life are associated with childhood asthma. Methods...
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Published in: | Clinical and experimental allergy 2015-09, Vol.45 (9), p.1439-1446 |
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creator | Oren, E. Rothers, J. Stern, D. A. Morgan, W. J. Halonen, M. Wright, A. L. |
description | Summary
Objectives
Wheezing in infancy has been associated with subsequent asthma, but whether cough similarly influences asthma risk has been little studied. We sought to determine whether prolonged cough and cough without cold in the first year of life are associated with childhood asthma.
Methods
Participants in the Infant Immune Study, a non‐selected birth cohort, were surveyed 7 times in the first 9 months of life regarding the presence of wheeze and cough. Cough for more than 28 days was defined as prolonged. Parents were asked at 1 year if the child ever coughed without a cold. Asthma was defined as parental report of physician diagnosis of asthma, with symptoms or medication use between 2 and 9 years. Logistic regression was used to assess adjusted odds for asthma associated with cough characteristics.
Results
A total of 24% (97) of children experienced prolonged cough and 23% (95) cough without cold in the first 9 months, respectively. Prolonged cough was associated with increased risk of asthma relative to brief cough (OR 3.57, CI: 1.88, 6.76), with the risk being particularly high among children of asthmatic mothers. Cough without cold (OR 3.13, 95% CI: 1.76, 5.57) was also independently associated with risk of childhood asthma. Both relations persisted after adjustment for wheeze and total IgE at age 1.
Conclusions and Clinical Relevance
Prolonged cough in infancy and cough without cold are associated with childhood asthma, independent of infant wheeze. These findings suggest that characteristics of cough in infancy are early markers of asthma susceptibility, particularly among children with maternal asthma. |
doi_str_mv | 10.1111/cea.12573 |
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Objectives
Wheezing in infancy has been associated with subsequent asthma, but whether cough similarly influences asthma risk has been little studied. We sought to determine whether prolonged cough and cough without cold in the first year of life are associated with childhood asthma.
Methods
Participants in the Infant Immune Study, a non‐selected birth cohort, were surveyed 7 times in the first 9 months of life regarding the presence of wheeze and cough. Cough for more than 28 days was defined as prolonged. Parents were asked at 1 year if the child ever coughed without a cold. Asthma was defined as parental report of physician diagnosis of asthma, with symptoms or medication use between 2 and 9 years. Logistic regression was used to assess adjusted odds for asthma associated with cough characteristics.
Results
A total of 24% (97) of children experienced prolonged cough and 23% (95) cough without cold in the first 9 months, respectively. Prolonged cough was associated with increased risk of asthma relative to brief cough (OR 3.57, CI: 1.88, 6.76), with the risk being particularly high among children of asthmatic mothers. Cough without cold (OR 3.13, 95% CI: 1.76, 5.57) was also independently associated with risk of childhood asthma. Both relations persisted after adjustment for wheeze and total IgE at age 1.
Conclusions and Clinical Relevance
Prolonged cough in infancy and cough without cold are associated with childhood asthma, independent of infant wheeze. These findings suggest that characteristics of cough in infancy are early markers of asthma susceptibility, particularly among children with maternal asthma.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/cea.12573</identifier><identifier>PMID: 26011047</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>allergy ; Asthma - epidemiology ; Asthma - etiology ; childhood asthma ; cough ; Cough - complications ; Cough - epidemiology ; Disease Susceptibility ; Female ; Humans ; Infant ; Infant, Newborn ; LRIs ; Male ; parental asthma ; Prospective Studies ; Risk Factors</subject><ispartof>Clinical and experimental allergy, 2015-09, Vol.45 (9), p.1439-1446</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><rights>Copyright © 2015 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4813-7d4f2cf29c8c088651ad166b9b81081681535256902f0d6f58ff69696a8b35233</citedby><cites>FETCH-LOGICAL-c4813-7d4f2cf29c8c088651ad166b9b81081681535256902f0d6f58ff69696a8b35233</cites><orcidid>0000-0001-7817-3516</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26011047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oren, E.</creatorcontrib><creatorcontrib>Rothers, J.</creatorcontrib><creatorcontrib>Stern, D. A.</creatorcontrib><creatorcontrib>Morgan, W. J.</creatorcontrib><creatorcontrib>Halonen, M.</creatorcontrib><creatorcontrib>Wright, A. L.</creatorcontrib><title>Cough during infancy and subsequent childhood asthma</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Summary
Objectives
Wheezing in infancy has been associated with subsequent asthma, but whether cough similarly influences asthma risk has been little studied. We sought to determine whether prolonged cough and cough without cold in the first year of life are associated with childhood asthma.
Methods
Participants in the Infant Immune Study, a non‐selected birth cohort, were surveyed 7 times in the first 9 months of life regarding the presence of wheeze and cough. Cough for more than 28 days was defined as prolonged. Parents were asked at 1 year if the child ever coughed without a cold. Asthma was defined as parental report of physician diagnosis of asthma, with symptoms or medication use between 2 and 9 years. Logistic regression was used to assess adjusted odds for asthma associated with cough characteristics.
Results
A total of 24% (97) of children experienced prolonged cough and 23% (95) cough without cold in the first 9 months, respectively. Prolonged cough was associated with increased risk of asthma relative to brief cough (OR 3.57, CI: 1.88, 6.76), with the risk being particularly high among children of asthmatic mothers. Cough without cold (OR 3.13, 95% CI: 1.76, 5.57) was also independently associated with risk of childhood asthma. Both relations persisted after adjustment for wheeze and total IgE at age 1.
Conclusions and Clinical Relevance
Prolonged cough in infancy and cough without cold are associated with childhood asthma, independent of infant wheeze. These findings suggest that characteristics of cough in infancy are early markers of asthma susceptibility, particularly among children with maternal asthma.</description><subject>allergy</subject><subject>Asthma - epidemiology</subject><subject>Asthma - etiology</subject><subject>childhood asthma</subject><subject>cough</subject><subject>Cough - complications</subject><subject>Cough - epidemiology</subject><subject>Disease Susceptibility</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>LRIs</subject><subject>Male</subject><subject>parental asthma</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kUtLLDEQhYMoOj4W_oFLg5vrojXvpDeCDL5g0I3iMqTTyXS8PR1Npq_Ovzc6OqhgZZFFfXU4VQeAfQSPUK5jY_URwkyQNTBChLMS51oHI1gxWgpZ0S2wndIDhJCwSm6CLcwhQpCKEaDjMEzbohmi76eF753uzaLQfVOkoU72abD9vDCt75o2hKbQad7O9C7YcLpLdu_j3wF352e348tycnNxNT6dlIZKRErRUIeNw5WRBkrJGdIN4ryuaomgRFwiRhhmvILYwYY7Jp3jVX5a1rlByA44Weo-DvXMNiZ7ibpTj9HPdFyooL363ul9q6bhv6KMVhiKLPD3QyCGvEqaq5lPxnad7m0YkkICciaEQDijBz_QhzDEPq_3TiEuCKaZOlxSJoaUonUrMwiqtyxUzkK9Z5HZP1_dr8jP42fgeAk8-84ufldS47PTT8lyOeHT3L6sJnT8p7I_wdT99YU6n3DOxb1QlLwCABKf0A</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Oren, E.</creator><creator>Rothers, J.</creator><creator>Stern, D. A.</creator><creator>Morgan, W. J.</creator><creator>Halonen, M.</creator><creator>Wright, A. L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7817-3516</orcidid></search><sort><creationdate>201509</creationdate><title>Cough during infancy and subsequent childhood asthma</title><author>Oren, E. ; Rothers, J. ; Stern, D. A. ; Morgan, W. J. ; Halonen, M. ; Wright, A. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4813-7d4f2cf29c8c088651ad166b9b81081681535256902f0d6f58ff69696a8b35233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>allergy</topic><topic>Asthma - epidemiology</topic><topic>Asthma - etiology</topic><topic>childhood asthma</topic><topic>cough</topic><topic>Cough - complications</topic><topic>Cough - epidemiology</topic><topic>Disease Susceptibility</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>LRIs</topic><topic>Male</topic><topic>parental asthma</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oren, E.</creatorcontrib><creatorcontrib>Rothers, J.</creatorcontrib><creatorcontrib>Stern, D. A.</creatorcontrib><creatorcontrib>Morgan, W. J.</creatorcontrib><creatorcontrib>Halonen, M.</creatorcontrib><creatorcontrib>Wright, A. L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oren, E.</au><au>Rothers, J.</au><au>Stern, D. A.</au><au>Morgan, W. J.</au><au>Halonen, M.</au><au>Wright, A. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cough during infancy and subsequent childhood asthma</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2015-09</date><risdate>2015</risdate><volume>45</volume><issue>9</issue><spage>1439</spage><epage>1446</epage><pages>1439-1446</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary
Objectives
Wheezing in infancy has been associated with subsequent asthma, but whether cough similarly influences asthma risk has been little studied. We sought to determine whether prolonged cough and cough without cold in the first year of life are associated with childhood asthma.
Methods
Participants in the Infant Immune Study, a non‐selected birth cohort, were surveyed 7 times in the first 9 months of life regarding the presence of wheeze and cough. Cough for more than 28 days was defined as prolonged. Parents were asked at 1 year if the child ever coughed without a cold. Asthma was defined as parental report of physician diagnosis of asthma, with symptoms or medication use between 2 and 9 years. Logistic regression was used to assess adjusted odds for asthma associated with cough characteristics.
Results
A total of 24% (97) of children experienced prolonged cough and 23% (95) cough without cold in the first 9 months, respectively. Prolonged cough was associated with increased risk of asthma relative to brief cough (OR 3.57, CI: 1.88, 6.76), with the risk being particularly high among children of asthmatic mothers. Cough without cold (OR 3.13, 95% CI: 1.76, 5.57) was also independently associated with risk of childhood asthma. Both relations persisted after adjustment for wheeze and total IgE at age 1.
Conclusions and Clinical Relevance
Prolonged cough in infancy and cough without cold are associated with childhood asthma, independent of infant wheeze. These findings suggest that characteristics of cough in infancy are early markers of asthma susceptibility, particularly among children with maternal asthma.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26011047</pmid><doi>10.1111/cea.12573</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7817-3516</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | allergy Asthma - epidemiology Asthma - etiology childhood asthma cough Cough - complications Cough - epidemiology Disease Susceptibility Female Humans Infant Infant, Newborn LRIs Male parental asthma Prospective Studies Risk Factors |
title | Cough during infancy and subsequent childhood asthma |
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