Sex-specific genetic effects in physical activity: results from a quantitative genetic analysis

The objective of this study is to present a model to estimate sex-specific genetic effects on physical activity (PA) levels and sedentary behaviour (SB) using three generation families. The sample consisted of 100 families covering three generations from Portugal. PA and SB were assessed via the Int...

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Published in:BMC medical genetics 2015-08, Vol.16 (1), p.58-58, Article 58
Main Authors: Diego, Vincent P, de Chaves, Raquel Nichele, Blangero, John, de Souza, Michele Caroline, Santos, Daniel, Gomes, Thayse Natacha, dos Santos, Fernanda Karina, Garganta, Rui, Katzmarzyk, Peter T, Maia, José A R
Format: Article
Language:English
Subjects:
Analysis of Variance
Cross-Sectional Studies
Estimates
Exercise
Female
Humans
Hypotheses
Inheritance Patterns - genetics
Likelihood Functions
Male
Metabolism
Models, Genetic
Motor Activity - genetics
Portugal
Quantitative genetics
Questionnaires
Sedentary Behavior
Sex Characteristics
Surveys and Questionnaires
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Summary:The objective of this study is to present a model to estimate sex-specific genetic effects on physical activity (PA) levels and sedentary behaviour (SB) using three generation families. The sample consisted of 100 families covering three generations from Portugal. PA and SB were assessed via the International Physical Activity Questionnaire short form (IPAQ-SF). Sex-specific effects were assessed by genotype-by-sex interaction (GSI) models and sex-specific heritabilities. GSI effects and heterogeneity were tested in the residual environmental variance. SPSS 17 and SOLAR v. 4.1 were used in all computations. The genetic component for PA and SB domains varied from low to moderate (11% to 46%), when analyzing both genders combined. We found GSI effects for vigorous PA (p = 0.02) and time spent watching television (WT) (p 
ISSN:1471-2350
1471-2350
DOI:10.1186/s12881-015-0207-9