Differential expression of hypothalamic, metabolic and inflammatory genes in response to short-term calorie restriction in juvenile obese- and lean-prone JCR rats

Background: Childhood obesity is an important early predictor of adult obesity and associated comorbidities. Common forms of obesity are underpinned by both environmental and genetic factors. However, the rising prevalence of obesity in genetically stable populations strongly suggests that contempor...

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Published in:Nutrition & diabetes 2015-08, Vol.5 (8), p.e178-e178
Main Authors: Diane, A, Pierce, W D, Mangat, R, Borthwick, F, Nelson, R, Russell, J C, Heth, C D, Jacobs, R L, Vine, D F, Proctor, S D
Format: Article
Language:English
Subjects:
38/90
631/443/319
Clinical Nutrition
Diabetes
Epidemiology
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
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original-article
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Summary:Background: Childhood obesity is an important early predictor of adult obesity and associated comorbidities. Common forms of obesity are underpinned by both environmental and genetic factors. However, the rising prevalence of obesity in genetically stable populations strongly suggests that contemporary lifestyle is a premier factor to the disease. In pediatric population, the current treatment/prevention options for obesity are lifestyle interventions such as caloric restriction (CR) and increase physical activity. In obese individuals, CR improves many metabolic parameters in peripheral tissues. Little is known about the effect of CR on the hypothalamus. This study aimed to assess the effect of CR on hypothalamic metabolic gene expression of young obese- and lean-prone animals. Methods: Male juvenile JCR:LA-cp obese-prone rats were freely fed (Obese-FF) or pair fed (Obese-FR) to lean-prone, free-feeding animals (Lean-FF). A group of lean-prone rats (Lean-FR) were matched for relative average degree of CR to Obese-FR rats. Results: In free-feeding conditions, obese-prone rats consumed more energy than lean-prone rats ( P
ISSN:2044-4052
2044-4052
DOI:10.1038/nutd.2015.28