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Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats
Status epilepticus (SE) is a severe condition that may lead to hippocampal cell loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death are excitotoxicity, neuroinflammation, and apoptosis. The objective of the present study is to test the hypothesis that DBS has anti-...
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| Published in: | Journal of neuroinflammation 2015-09, Vol.12 (1), p.162, Article 162 |
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| container_issue | 1 |
| container_start_page | 162 |
| container_title | Journal of neuroinflammation |
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| creator | Amorim, Beatriz O Covolan, Luciene Ferreira, Elenn Brito, José Geraldo Nunes, Diego P de Morais, David G Nobrega, José N Rodrigues, Antonio M deAlmeida, Antonio Carlos G Hamani, Clement |
| description | Status epilepticus (SE) is a severe condition that may lead to hippocampal cell loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death are excitotoxicity, neuroinflammation, and apoptosis.
The objective of the present study is to test the hypothesis that DBS has anti-inflammatory and antiapoptotic effects when applied during SE.
Rats undergoing pilocarpine-induced SE were treated with anterior thalamic nucleus (AN) deep brain stimulation (DBS). Inflammatory changes and caspase 3 activity were measured within 1 week of treatment.
In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor α (TNFα).
DBS has anti-inflammatory and antiapoptotic effects when given to animals undergoing status. |
| doi_str_mv | 10.1186/s12974-015-0384-7 |
| format | article |
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The objective of the present study is to test the hypothesis that DBS has anti-inflammatory and antiapoptotic effects when applied during SE.
Rats undergoing pilocarpine-induced SE were treated with anterior thalamic nucleus (AN) deep brain stimulation (DBS). Inflammatory changes and caspase 3 activity were measured within 1 week of treatment.
In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor α (TNFα).
DBS has anti-inflammatory and antiapoptotic effects when given to animals undergoing status.</description><identifier>ISSN: 1742-2094</identifier><identifier>EISSN: 1742-2094</identifier><identifier>DOI: 10.1186/s12974-015-0384-7</identifier><identifier>PMID: 26337974</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analysis ; Analysis of Variance ; Animals ; Anti-inflammatory drugs ; Apoptosis - drug effects ; Apoptosis - physiology ; Care and treatment ; Caspase 3 - metabolism ; Cell death ; Complications and side effects ; Cytokines - metabolism ; Deep Brain Stimulation - methods ; Disease Models, Animal ; Electroencephalography ; Encephalitis - etiology ; Encephalitis - therapy ; Epilepsy ; Hippocampus - metabolism ; Interleukins ; Male ; Muscarinic Agonists ; Neurophysiology ; Pilocarpine - toxicity ; Rats ; Rats, Wistar ; Risk factors ; Seizures (Medicine) ; Short Report ; Status Epilepticus - chemically induced ; Status Epilepticus - complications ; Status Epilepticus - pathology</subject><ispartof>Journal of neuroinflammation, 2015-09, Vol.12 (1), p.162, Article 162</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Amorim et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-c8c59ba491d6543bc31e939ccf885ebd3d9a31e6d6a75d5abf6bcc31f51f40743</citedby><cites>FETCH-LOGICAL-c494t-c8c59ba491d6543bc31e939ccf885ebd3d9a31e6d6a75d5abf6bcc31f51f40743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558969/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1780157354?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26337974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amorim, Beatriz O</creatorcontrib><creatorcontrib>Covolan, Luciene</creatorcontrib><creatorcontrib>Ferreira, Elenn</creatorcontrib><creatorcontrib>Brito, José Geraldo</creatorcontrib><creatorcontrib>Nunes, Diego P</creatorcontrib><creatorcontrib>de Morais, David G</creatorcontrib><creatorcontrib>Nobrega, José N</creatorcontrib><creatorcontrib>Rodrigues, Antonio M</creatorcontrib><creatorcontrib>deAlmeida, Antonio Carlos G</creatorcontrib><creatorcontrib>Hamani, Clement</creatorcontrib><title>Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats</title><title>Journal of neuroinflammation</title><addtitle>J Neuroinflammation</addtitle><description>Status epilepticus (SE) is a severe condition that may lead to hippocampal cell loss and epileptogenesis. Some of the mechanisms associated with SE-induced cell death are excitotoxicity, neuroinflammation, and apoptosis.
The objective of the present study is to test the hypothesis that DBS has anti-inflammatory and antiapoptotic effects when applied during SE.
Rats undergoing pilocarpine-induced SE were treated with anterior thalamic nucleus (AN) deep brain stimulation (DBS). Inflammatory changes and caspase 3 activity were measured within 1 week of treatment.
In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor α (TNFα).
DBS has anti-inflammatory and antiapoptotic effects when given to animals undergoing status.</description><subject>Analysis</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Anti-inflammatory drugs</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - physiology</subject><subject>Care and treatment</subject><subject>Caspase 3 - metabolism</subject><subject>Cell death</subject><subject>Complications and side effects</subject><subject>Cytokines - metabolism</subject><subject>Deep Brain Stimulation - methods</subject><subject>Disease Models, Animal</subject><subject>Electroencephalography</subject><subject>Encephalitis - etiology</subject><subject>Encephalitis - therapy</subject><subject>Epilepsy</subject><subject>Hippocampus - metabolism</subject><subject>Interleukins</subject><subject>Male</subject><subject>Muscarinic Agonists</subject><subject>Neurophysiology</subject><subject>Pilocarpine - toxicity</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Risk factors</subject><subject>Seizures (Medicine)</subject><subject>Short Report</subject><subject>Status Epilepticus - chemically induced</subject><subject>Status Epilepticus - complications</subject><subject>Status Epilepticus - pathology</subject><issn>1742-2094</issn><issn>1742-2094</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptUU1rHiEYlNLQfLQ_IJew0PMmuuq6XgIhbT4g0EtyK4irj6lhVzfqFvLv65s3TRMoHtTHmWGcQeiQ4GNChv4kk04K1mLCW0wH1ooPaI8I1rUdluzjm_Mu2s_5AWPa8b77hHa7nlJRqXvo5zeApRmT9qHJxc_rpIuPofHBrgZyo0PxeolLicWberPPk9YHN-l51iWmpwacA1Ny5TSw-AmWDTTpkj-jHaenDF9e9gN0d_H99vyqvflxeX1-dtMaJllpzWC4HDWTxPac0dFQApJKY9wwcBgttVLXUW97LbjlenT9aCrIceIYFoweoNOt7rKOM1gDoSQ9qSX5WacnFbVX71-C_6Xu42_FOB9kL6vA1xeBFB9XyEU9xDWF6lkRMdR8BeXsH-peT6BqBLGKmdlno844I7wjlOKKOv4Pqi4LszcxgKsRvSeQLcGkmHMC92qcYLXpWW17VtWH2vSsROUcvf3xK-NvsfQPPPWk4w</recordid><startdate>20150904</startdate><enddate>20150904</enddate><creator>Amorim, Beatriz O</creator><creator>Covolan, Luciene</creator><creator>Ferreira, Elenn</creator><creator>Brito, José Geraldo</creator><creator>Nunes, Diego P</creator><creator>de Morais, David G</creator><creator>Nobrega, José N</creator><creator>Rodrigues, Antonio M</creator><creator>deAlmeida, Antonio Carlos G</creator><creator>Hamani, Clement</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20150904</creationdate><title>Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats</title><author>Amorim, Beatriz O ; 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Some of the mechanisms associated with SE-induced cell death are excitotoxicity, neuroinflammation, and apoptosis.
The objective of the present study is to test the hypothesis that DBS has anti-inflammatory and antiapoptotic effects when applied during SE.
Rats undergoing pilocarpine-induced SE were treated with anterior thalamic nucleus (AN) deep brain stimulation (DBS). Inflammatory changes and caspase 3 activity were measured within 1 week of treatment.
In pilocarpine-treated rats, DBS countered the significant increase in hippocampal caspase 3 activity and interleukin-6 (IL-6) levels that follows SE but had no effect on tumor necrosis factor α (TNFα).
DBS has anti-inflammatory and antiapoptotic effects when given to animals undergoing status.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26337974</pmid><doi>10.1186/s12974-015-0384-7</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neuroinflammation, 2015-09, Vol.12 (1), p.162, Article 162 |
| issn | 1742-2094 1742-2094 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4558969 |
| source | Open Access: PubMed Central; Publicly Available Content (ProQuest) |
| subjects | Analysis Analysis of Variance Animals Anti-inflammatory drugs Apoptosis - drug effects Apoptosis - physiology Care and treatment Caspase 3 - metabolism Cell death Complications and side effects Cytokines - metabolism Deep Brain Stimulation - methods Disease Models, Animal Electroencephalography Encephalitis - etiology Encephalitis - therapy Epilepsy Hippocampus - metabolism Interleukins Male Muscarinic Agonists Neurophysiology Pilocarpine - toxicity Rats Rats, Wistar Risk factors Seizures (Medicine) Short Report Status Epilepticus - chemically induced Status Epilepticus - complications Status Epilepticus - pathology |
| title | Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats |
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