Clinical characteristics of protracted bacterial bronchitis in Chinese infants

Protracted bacterial bronchitis (PBB) is the common cause of chronic cough in children worldwide, but its etiology has not been fully recognized in China. We retrospectively investigated a total of 66 hospitalized infants under the age of three years with chronic wet cough enrolled in the Affiliated...

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Bibliographic Details
Published in:Scientific reports 2015-09, Vol.5 (1), p.13731-13731, Article 13731
Main Authors: Wang, Yuqing, Hao, Chuangli, Chi, FanFan, Yu, Xingmei, Sun, Huiquan, Huang, Li, Wang, Meijuan, Ji, Wei, Yan, Yongdong, Zhu, Hong, Shao, Xuejun
Format: Article
Language:English
Subjects:
692/1807/1809
692/308/3187
Age Distribution
Alveoli
Bacterial Infections - diagnosis
Bacterial Infections - epidemiology
Bacterial Infections - microbiology
Bronchitis
Bronchitis, Chronic - diagnosis
Bronchitis, Chronic - epidemiology
Bronchitis, Chronic - microbiology
Bronchoscopy
CD16 antigen
CD19 antigen
CD23 antigen
CD3 antigen
CD4 antigen
CD56 antigen
Child, Preschool
Children
China - epidemiology
Comorbidity
Cough
Cough - diagnosis
Cough - epidemiology
Etiology
Health risk assessment
Humanities and Social Sciences
Humans
Infant
Infant, Newborn
Infants
Lymphocytes
Male
multidisciplinary
Prevalence
Respiratory Sounds - diagnosis
Respiratory tract
Risk Factors
Science
Sex Distribution
Streptococcus infections
Symptom Assessment - statistics & numerical data
Wheezing
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Summary:Protracted bacterial bronchitis (PBB) is the common cause of chronic cough in children worldwide, but its etiology has not been fully recognized in China. We retrospectively investigated a total of 66 hospitalized infants under the age of three years with chronic wet cough enrolled in the Affiliated Children’s Hospital of Soochow University from October 2010 to March 2014. All patients underwent bronchoscopy and broncho-alveolar lavage (BAL) samples were processed for microbiological and cytological analysis. Of 66 patients with wet cough, 50 (75.8%) were diagnosed with PBB. In the PBB group, wet cough was accompanied by wheezing (90%). Airway malacia were identified in 22 cases (44%). The clinical manifestations of PBB with airway malacia did not differ from those without malacia. Haemophilus influenzae (47.4%) and Streptococcus pneumoniae (36.8%) were the most commonly identified pathogens. Furthermore, CD3 + and CD3 + CD4 + cells were significantly lower in the PBB group (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep13731