Functionalized ultrathin palladium nanosheets as patches for HepG2 cancer cells

Flexible, charged Pd nanosheets were prepared by using short chain thiolated carboxylic acids and amines. They could wrap around amine or hydroxyl functionalized micron-sized spheres driven by electrostatic interactions. Upon incubation with HepG2 cells, the positively charged cysteamine (CA) functi...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-09, Vol.51 (75), p.14171-14174
Main Authors: Pan, Yung-Tin, Smith, Cartney E, Kwok, Kam Sang, Chen, Jinrong, Kong, Hyunjoon, Yang, Hong
Format: Article
Language:English
Subjects:
Amines
Amines - chemistry
Amines - pharmacology
Cancer
Carboxylic acids
Carboxylic Acids - chemistry
Carboxylic Acids - pharmacology
Cell death
Cell Death - drug effects
Chains
Charging
Cysteamine
Dose-Response Relationship, Drug
Hep G2 Cells
Humans
Metal Nanoparticles - chemistry
Nanostructure
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Palladium
Palladium - chemistry
Palladium - pharmacology
Particle Size
Static Electricity
Structure-Activity Relationship
Surface Properties
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Summary:Flexible, charged Pd nanosheets were prepared by using short chain thiolated carboxylic acids and amines. They could wrap around amine or hydroxyl functionalized micron-sized spheres driven by electrostatic interactions. Upon incubation with HepG2 cells, the positively charged cysteamine (CA) functionalized Pd nanosheets exhibited a much higher cytotoxicity, showing more than 80% cell death at 100 ppm than the negatively charged 3-mercaptopropionic acid (MPA) functionalized ones which caused 30% cell death. The results show through surface functionalization Pd nanosheets can be modified to interact differently with HepG2 cancerous cells, resulting in varied cytotoxicity.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc04727g