Delayed BCG vaccination results in minimal alterations in T cell immunogenicity of acellular pertussis and tetanus immunizations in HIV-exposed infants

Highlights • Delaying BCG until 8 weeks did not alter T-cell proliferation to BP or TT. • Infants immunized with BCG at birth had higher CD4+ T cell proliferation to SEB. • Infants BCG-immunized at birth had higher CD8+ IL-2 expression to BP. • Infants BCG-immunized at birth had higher CD4+ and CD8+...

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Bibliographic Details
Published in:Vaccine 2015-09, Vol.33 (38), p.4782-4789
Main Authors: Blakney, Anna K, Tchakoute, Christophe Toukam, Hesseling, Anneke C, Kidzeru, Elvis B, Jones, Christine E, Passmore, Jo-Ann S, Sodora, Donald L, Gray, Clive M, Jaspan, Heather B
Format: Article
Language:English
Subjects:
Age
Allergy and Immunology
BCG vaccine
BCG Vaccine - administration & dosage
Birth weight
Cell Proliferation
Cytokines
Cytokines - biosynthesis
Environmental Exposure
Epigenetics
Female
HIV
HIV Infections
Human immunodeficiency virus
Humans
Immunization
Immunization Schedule
Immunogenicity
Infant
Infants
Infections
Lymphocytes
Male
Mycobacterium
Pediatrics
Pertussis
Pertussis Vaccine - administration & dosage
Pertussis Vaccine - immunology
Poliomyelitis
Software
Studies
T cell
T-Lymphocytes - immunology
Tetanus
Tetanus Toxoid - administration & dosage
Tetanus Toxoid - immunology
Time Factors
Tuberculosis
Vaccines
Whooping cough
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Summary:Highlights • Delaying BCG until 8 weeks did not alter T-cell proliferation to BP or TT. • Infants immunized with BCG at birth had higher CD4+ T cell proliferation to SEB. • Infants BCG-immunized at birth had higher CD8+ IL-2 expression to BP. • Infants BCG-immunized at birth had higher CD4+ and CD8+ IL-13 expressions to BP. • Delaying BCG had no effect on overall T cell cytokine polyfunctionality.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.07.096