Androgen Receptor Coregulator CTBP1-AS Is Associated With Polycystic Ovary Syndrome in Chinese Women: A Preliminary Study

Polycystic ovary syndrome (PCOS) is currently considered a predominantly hyperandrogenic syndrome. In theory, hyperandrogenism can be caused by high level of testosterone (T) as well as by enhanced androgen receptor (AR) activity. C-Terminal binding protein 1 antisense (CTBP1-AS) was a novel long no...

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Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2015-07, Vol.22 (7), p.829-837
Main Authors: Liu, Zhenteng, Hao, Cuifang, Song, Dehua, Zhang, Ning, Bao, Hongchu, Qu, Qinglan
Format: Article
Language:English
Subjects:
Adult
Alcohol Oxidoreductases - biosynthesis
Alcohol Oxidoreductases - genetics
Asian Continental Ancestry Group - genetics
DNA-Binding Proteins - biosynthesis
DNA-Binding Proteins - genetics
Embryology
Female
Humans
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Original
Original Article
Polycystic Ovary Syndrome - genetics
Polycystic Ovary Syndrome - metabolism
Receptors, Androgen - physiology
Reproductive Medicine
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Summary:Polycystic ovary syndrome (PCOS) is currently considered a predominantly hyperandrogenic syndrome. In theory, hyperandrogenism can be caused by high level of testosterone (T) as well as by enhanced androgen receptor (AR) activity. C-Terminal binding protein 1 antisense (CTBP1-AS) was a novel long noncoding RNA (lncRNA) to regulate AR activity. In this study, we found that expression level of CTBP1-AS in peripheral blood leukocytes was significantly higher in women with PCOS than that in controls after adjustment for age and body mass index (BMI). Individuals having higher expression of CTBP1-AS had significantly greater disease risk than those having lower expression. We also identified expression of CTBP1-AS as an independent risk factor for PCOS. A positive correlation was observed between the CTBP1-AS expression and the total T (TT) concentration either unadjusted or after adjusting for age, BMI, and homeostatic model assessment insulin resistance. Taken together, our current study presented the first evidence that the lncRNA CTBP1-AS, a novel AR modulator, is associated with PCOS in Chinese population and established the possibility that abnormal CTBP1-AS expression is a risk factor for PCOS and it is a predictor of variability in serum TT level in Chinese women with PCOS.
ISSN:1933-7191
1933-7205
DOI:10.1177/1933719114565037