Androgen Receptor Coregulator CTBP1-AS Is Associated With Polycystic Ovary Syndrome in Chinese Women: A Preliminary Study

• Published in: Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2015-07, Vol.22 (7), p.829-837
• Main Authors: Liu, Zhenteng, Hao, Cuifang, Song, Dehua, Zhang, Ning, Bao, Hongchu, Qu, Qinglan
• Format: Article
• Language: English
• Subjects: Adult; Alcohol Oxidoreductases - biosynthesis; Alcohol Oxidoreductases - genetics; Asian Continental Ancestry Group - genetics; DNA-Binding Proteins - biosynthesis; DNA-Binding Proteins - genetics; Embryology; Female; Humans; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Original; Original Article; Polycystic Ovary Syndrome - genetics; Polycystic Ovary Syndrome - metabolism; Receptors, Androgen - physiology; Reproductive Medicine
• ISSN: 1933-7191; 1933-7205
• DOI: 10.1177/1933719114565037

Polycystic ovary syndrome (PCOS) is currently considered a predominantly hyperandrogenic syndrome. In theory, hyperandrogenism can be caused by high level of testosterone (T) as well as by enhanced androgen receptor (AR) activity. C-Terminal binding protein 1 antisense (CTBP1-AS) was a novel long noncoding RNA (lncRNA) to regulate AR activity. In this study, we found that expression level of CTBP1-AS in peripheral blood leukocytes was significantly higher in women with PCOS than that in controls after adjustment for age and body mass index (BMI). Individuals having higher expression of CTBP1-AS had significantly greater disease risk than those having lower expression. We also identified expression of CTBP1-AS as an independent risk factor for PCOS. A positive correlation was observed between the CTBP1-AS expression and the total T (TT) concentration either unadjusted or after adjusting for age, BMI, and homeostatic model assessment insulin resistance. Taken together, our current study presented the first evidence that the lncRNA CTBP1-AS, a novel AR modulator, is associated with PCOS in Chinese population and established the possibility that abnormal CTBP1-AS expression is a risk factor for PCOS and it is a predictor of variability in serum TT level in Chinese women with PCOS.