Profiling of plasma metabolites in canine oral melanoma using gas chromatography-mass spectrometry

Malignant melanoma is one of the most common and aggressive tumors in the oral cavity of dog. The tumor has a poor prognosis, and methods for diagnosis and prediction of prognosis after treatment are required. Here, we examined metabolite profiling using gas chromatography-mass spectrometry (GC-MS)...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2015, Vol.77(8), pp.1025-1028
Main Authors: KAWABE, Mifumi, BABA, Yuta, TAMAI, Reo, YAMAMOTO, Ryohei, KOMORI, Masayuki, MORI, Takashi, TAKENAKA, Shigeo
Format: Article
Language:English
Subjects:
Amino Acids - blood
Animals
Biomarkers - blood
canine oral malignant melanoma
Case-Control Studies
Clinical Pathology
Dog Diseases - blood
Dog Diseases - diagnosis
Dogs - blood
Energy Metabolism
Female
Gas Chromatography-Mass Spectrometry - veterinary
GC-MS
Male
Melanoma - blood
Melanoma - diagnosis
Melanoma - veterinary
metabolomics
Mouth Neoplasms - blood
Mouth Neoplasms - diagnosis
Mouth Neoplasms - veterinary
Prognosis
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Summary:Malignant melanoma is one of the most common and aggressive tumors in the oral cavity of dog. The tumor has a poor prognosis, and methods for diagnosis and prediction of prognosis after treatment are required. Here, we examined metabolite profiling using gas chromatography-mass spectrometry (GC-MS) for development of a discriminant model for evaluation of prognosis. Metabolite profiles were evaluated in healthy and melanoma plasma samples using orthogonal projection to latent structure using discriminant analysis (OPLS-DA). Cases that were predicted to be healthy using the OPLS discriminant model had no advanced lesions after radiation therapy. These results indicate that metabolite profiling may be useful in diagnosis and prediction of prognosis of canine malignant melanoma.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.14-0641