Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast

We demonstrate that Magnetic Particle Imaging (MPI) enables monitoring of cellular grafts with high contrast, sensitivity and quantitativeness. MPI directly detects the intense magnetization of iron-oxide tracers using low-frequency magnetic fields. MPI is safe, noninvasive and offers superb sensiti...

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Bibliographic Details
Published in:Scientific reports 2015-09, Vol.5 (1), p.14055, Article 14055
Main Authors: Zheng, Bo, Vazin, Tandis, Goodwill, Patrick W., Conway, Anthony, Verma, Aradhana, Ulku Saritas, Emine, Schaffer, David, Conolly, Steven M.
Format: Article
Language:English
Subjects:
631/1647/245/2160
631/61/2320
639/166/985
Animals
Cell Differentiation
Cell Tracking - methods
Computer engineering
Embryonic Stem Cells - cytology
Embryonic Stem Cells - metabolism
Female
Humanities and Social Sciences
Humans
Iron
Iron - metabolism
Magnetic fields
Magnetic Resonance Imaging - methods
Magnetite Nanoparticles
multidisciplinary
Neuroimaging
Radiation
Rats
Reproducibility of Results
Scanners
Science
Sensitivity and Specificity
Staining and Labeling
Tracers
Transplants & implants
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Summary:We demonstrate that Magnetic Particle Imaging (MPI) enables monitoring of cellular grafts with high contrast, sensitivity and quantitativeness. MPI directly detects the intense magnetization of iron-oxide tracers using low-frequency magnetic fields. MPI is safe, noninvasive and offers superb sensitivity, with great promise for clinical translation and quantitative single-cell tracking. Here we report the first MPI cell tracking study, showing 200-cell detection in vitro and in vivo monitoring of human neural graft clearance over 87 days in rat brain.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep14055