Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder

Highlights • This meta-analysis confirms a robust link between IL-6, CRP and major depression. • The role of TNF-α and IL-1β in major depression remains uncertain. • Further mechanistic and immunotherapeutic studies on IL-6 and CRP are needed.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2015-10, Vol.49, p.206-215
Main Authors: Haapakoski, Rita, Mathieu, Julia, Ebmeier, Klaus P, Alenius, Harri, Kivimäki, Mika
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
C-reactive protein
C-Reactive Protein - immunology
C-Reactive Protein - metabolism
Cumulative meta-analysis
Depressive Disorder, Major - blood
Depressive Disorder, Major - complications
Depressive Disorder, Major - immunology
Female
Humans
Inflammation
Inflammation - blood
Inflammation - complications
Inflammation - immunology
Inflammation Mediators - blood
Inflammation Mediators - immunology
Interleukin-1beta - blood
Interleukin-1beta - immunology
Interleukin-1β
Interleukin-6
Interleukin-6 - blood
Interleukin-6 - immunology
Major depression
Male
Psychiatry
Tumor Necrosis Factor-alpha - blood
Tumor Necrosis Factor-alpha - immunology
Tumour necrosis factor-α
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Description
Summary:Highlights • This meta-analysis confirms a robust link between IL-6, CRP and major depression. • The role of TNF-α and IL-1β in major depression remains uncertain. • Further mechanistic and immunotherapeutic studies on IL-6 and CRP are needed.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2015.06.001