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Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder

Highlights • This meta-analysis confirms a robust link between IL-6, CRP and major depression. • The role of TNF-α and IL-1β in major depression remains uncertain. • Further mechanistic and immunotherapeutic studies on IL-6 and CRP are needed.

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Published in:	Brain, behavior, and immunity behavior, and immunity, 2015-10, Vol.49, p.206-215
Main Authors:	Haapakoski, Rita, Mathieu, Julia, Ebmeier, Klaus P, Alenius, Harri, Kivimäki, Mika
Format:	Article
Language:	English
Subjects:	Adult Allergy and Immunology C-reactive protein C-Reactive Protein - immunology C-Reactive Protein - metabolism Cumulative meta-analysis Depressive Disorder, Major - blood Depressive Disorder, Major - complications Depressive Disorder, Major - immunology Female Humans Inflammation Inflammation - blood Inflammation - complications Inflammation - immunology Inflammation Mediators - blood Inflammation Mediators - immunology Interleukin-1beta - blood Interleukin-1beta - immunology Interleukin-1β Interleukin-6 Interleukin-6 - blood Interleukin-6 - immunology Major depression Male Psychiatry Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - immunology Tumour necrosis factor-α
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description	Highlights • This meta-analysis confirms a robust link between IL-6, CRP and major depression. • The role of TNF-α and IL-1β in major depression remains uncertain. • Further mechanistic and immunotherapeutic studies on IL-6 and CRP are needed.
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subjects	Adult Allergy and Immunology C-reactive protein C-Reactive Protein - immunology C-Reactive Protein - metabolism Cumulative meta-analysis Depressive Disorder, Major - blood Depressive Disorder, Major - complications Depressive Disorder, Major - immunology Female Humans Inflammation Inflammation - blood Inflammation - complications Inflammation - immunology Inflammation Mediators - blood Inflammation Mediators - immunology Interleukin-1beta - blood Interleukin-1beta - immunology Interleukin-1β Interleukin-6 Interleukin-6 - blood Interleukin-6 - immunology Major depression Male Psychiatry Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - immunology Tumour necrosis factor-α
title	Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder
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