The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer's disease (AD). Cognitive deficit is related to alterations of neurotrophic factors level such as brain-deriv...

Full description

Saved in:
Bibliographic Details
Published in:Aging and disease 2015-10, Vol.6 (5), p.331-341
Main Authors: Budni, Josiane, Bellettini-Santos, Tatiani, Mina, Francielle, Garcez, Michelle Lima, Zugno, Alexandra Ioppi
Format: Article
Language:English
Subjects:
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer's disease (AD). Cognitive deficit is related to alterations of neurotrophic factors level such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF). These strong relationship between aging and AD is important to investigate the time which they overlap, as well as, the pathophysiological mechanism in each event. Considering that aging and AD are related to cognitive impairment, here we discuss the involving these neurotrophic factors in the aging process and AD.
ISSN:2152-5250
2152-5250
DOI:10.14336/AD.2015.0825