Stress exacerbates neuron loss and microglia proliferation in a rat model of excitotoxic lower motor neuron injury

Highlights • Stress exacerbates excitotoxic killing of spinal cord motor neurons. • Stress increases microglia proliferation at and beyond the site of neuron cell death. • Stress is an unappreciated disease‐modifying factor in neurological conditions.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2015-10, Vol.49, p.246-254
Main Authors: Puga, Denise A, Tovar, C. Amy, Guan, Zhen, Gensel, John C, Lyman, Matthew S, McTigue, Dana M, Popovich, Phillip G
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Cell Proliferation
Disease Models, Animal
Excitatory Amino Acid Agonists - pharmacology
Female
Glucocorticoid receptor
Glucocorticoids
Glutamate
Glutamic Acid - pharmacology
Hypothalamic–pituitary–adrenal axis
Microglia
Microglia - drug effects
Microglia - physiology
Motor Neurons - drug effects
Motor Neurons - pathology
Neuroinflammation
Psychiatry
Rats
Rats, Sprague-Dawley
Restraint, Physical
Spinal Cord - drug effects
Spinal Cord - pathology
Spinal Cord - physiopathology
Spinal Cord Injuries - pathology
Spinal Cord Injuries - physiopathology
Spinal cord injury
Stress
Stress, Psychological - pathology
Stress, Psychological - physiopathology
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Description
Summary:Highlights • Stress exacerbates excitotoxic killing of spinal cord motor neurons. • Stress increases microglia proliferation at and beyond the site of neuron cell death. • Stress is an unappreciated disease‐modifying factor in neurological conditions.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2015.06.006