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Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning

Glucose-induced insulin secretion is an essential function of pancreatic β-cells that is partially lost in individuals affected by Type 2 diabetes. This unique property of β-cells is acquired through a poorly understood postnatal maturation process involving major modifications in gene expression pr...

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Published in:Nature communications 2015-09, Vol.6 (1), p.8084-8084, Article 8084
Main Authors: Jacovetti, Cécile, Matkovich, Scot J., Rodriguez-Trejo, Adriana, Guay, Claudiane, Regazzi, Romano
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description Glucose-induced insulin secretion is an essential function of pancreatic β-cells that is partially lost in individuals affected by Type 2 diabetes. This unique property of β-cells is acquired through a poorly understood postnatal maturation process involving major modifications in gene expression programs. Here we show that β-cell maturation is associated with changes in microRNA expression induced by the nutritional transition that occurs at weaning. When mimicked in newborn islet cells, modifications in the level of specific microRNAs result in a switch in the expression of metabolic enzymes and cause the acquisition of glucose-induced insulin release. Our data suggest microRNAs have a central role in postnatal β-cell maturation and in the determination of adult functional β-cell mass. A better understanding of the events governing β-cell maturation may help understand why some individuals are predisposed to developing diabetes and could lead to new strategies for the treatment of this common metabolic disease. Pancreatic β-cells are less responsive to changes in glucose concentration in newborn than in adult rats. Here, the authors show that functional β-cell maturation is associated with changes in miRNA expression induced by nutritional shifts at the suckling-to-weaning transition.
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subjects 13/2
13/51
38
38/109
38/61
38/77
38/91
631/337/384/331
64/86
692/163
692/308
692/700/2814
Animals
Cell Differentiation - genetics
Cells, Cultured
Diabetes Mellitus, Type 2 - genetics
Flow Cytometry
Gene Expression Regulation, Developmental
Humanities and Social Sciences
Immunohistochemistry
Insulin - metabolism
Insulin Secretion
Insulin-Secreting Cells - metabolism
Islets of Langerhans - metabolism
MicroRNAs - genetics
multidisciplinary
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Science
Science (multidisciplinary)
Weaning
title Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning
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