Surviving apoptosis: life–death signaling in single cells

Highlights • TNF family death ligands activate both death and nondeath signaling pathways. • Cells surviving death stimuli may enter adaptive, death-resistant states. • Cell-to-cell variability in life–death signaling impacts cell fate decisions. • The evolutionary advantages of variability in life–...

Full description

Saved in:
Bibliographic Details
Published in:Trends in cell biology 2015-08, Vol.25 (8), p.446-458
Main Authors: Flusberg, Deborah A, Sorger, Peter K
Format: Article
Language:English
Subjects:
Animals
apoptosis
Apoptosis - physiology
Cell Death - physiology
cell fate
Cell Survival - physiology
death ligand
Humans
life–death decision
Pathology
Receptors, Death Domain - metabolism
Signal Transduction - physiology
survival
TNF-Related Apoptosis-Inducing Ligand - metabolism
variability
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • TNF family death ligands activate both death and nondeath signaling pathways. • Cells surviving death stimuli may enter adaptive, death-resistant states. • Cell-to-cell variability in life–death signaling impacts cell fate decisions. • The evolutionary advantages of variability in life–death signaling are discussed.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2015.03.003