Rise of multiple insecticide resistance in Anopheles funestus in Malawi: a major concern for malaria vector control

Deciphering the dynamics and evolution of insecticide resistance in malaria vectors is crucial for successful vector control. This study reports an increase of resistance intensity and a rise of multiple insecticide resistance in Anopheles funestus in Malawi leading to reduced bed net efficacy. Anop...

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Bibliographic Details
Published in:Malaria journal 2015-09, Vol.14 (1), p.344, Article 344
Main Authors: Riveron, Jacob M, Chiumia, Martin, Menze, Benjamin D, Barnes, Kayla G, Irving, Helen, Ibrahim, Sulaiman S, Weedall, Gareth D, Mzilahowa, Themba, Wondji, Charles S
Format: Article
Language:English
Subjects:
Animals
Anopheles - drug effects
Anopheles - genetics
Care and treatment
Complications and side effects
Control
Development and progression
Disease susceptibility
Female
Health aspects
Insect Vectors - drug effects
Insect Vectors - genetics
Insecticide Resistance - genetics
Insecticides - pharmacology
Malaria
Malaria - transmission
Malawi - epidemiology
Male
Mosquito Control - statistics & numerical data
Mutation
Strategic planning (Business)
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Summary:Deciphering the dynamics and evolution of insecticide resistance in malaria vectors is crucial for successful vector control. This study reports an increase of resistance intensity and a rise of multiple insecticide resistance in Anopheles funestus in Malawi leading to reduced bed net efficacy. Anopheles funestus group mosquitoes were collected in southern Malawi and the species composition, Plasmodium infection rate, susceptibility to insecticides and molecular bases of the resistance were analysed. Mosquito collection revealed a predominance of An. funestus group mosquitoes with a high hybrid rate (12.2 %) suggesting extensive species hybridization. An. funestus sensu stricto was the main Plasmodium vector (4.8 % infection). Consistently high levels of resistance to pyrethroid and carbamate insecticides were recorded and had increased between 2009 and 2014. Furthermore, the 2014 collection exhibited multiple insecticide resistance, notably to DDT, contrary to 2009. Increased pyrethroid resistance correlates with reduced efficacy of bed nets (
ISSN:1475-2875
1475-2875
DOI:10.1186/s12936-015-0877-y