Protein-Assisted DNA Looping: A Delicate Balance among Interactions, Mechanics, and Entropy

DNA looping is a unique process demonstrated when two distant sites on the biopolymer molecule bind. It is frequently observed in living systems where DNA looping is critically important for many cellular processes, including gene expression and regulation, DNA replication and recombination, DNA rep...

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Bibliographic Details
Published in:Biophysical journal 2015-08, Vol.109 (3), p.459-460
Main Author: Kolomeisky, Anatoly B.
Format: Article
Language:English
Subjects:
Biopolymers
Chromosomes
Deoxyribonucleic acid
DNA
DNA - chemistry
DNA repair
DNA-Binding Proteins - chemistry
Molecular Dynamics Simulation
Molecules
New and Notable
Nucleic Acid Conformation
Proteins
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Summary:DNA looping is a unique process demonstrated when two distant sites on the biopolymer molecule bind. It is frequently observed in living systems where DNA looping is critically important for many cellular processes, including gene expression and regulation, DNA replication and recombination, DNA repair, chromosome segregation, and many others (1,2). In nature, the formation of cyclic DNA or DNA with loops is usually assisted by various types of protein molecules. A simultaneous binding of a single protein molecule to two different binding sites on DNA creates a loop.
ISSN:0006-3495
1542-0086
DOI:10.1016/j.bpj.2015.06.055