Effects of narcotic analgesic drugs on human Oddi's sphincter motility

To assess the effects of intramuscular analgesics (morphine, Ap-237, pethidine and tramadol) on human Oddi's sphincter motility with choledochoscope manometry. A total of 70 patients having T tubes after cholecystectomy and choledochotomy were assessed by choledochoscope manometry. They were ra...

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Published in:World journal of gastroenterology : WJG 2004-10, Vol.10 (19), p.2901-2904
Main Authors: Wu, Shuo-Dong, Zhang, Zhen-Hai, Jin, Jun-Zhe, Kong, Jing, Wang, Wei, Zhang, Qiang, Li, Dong-Yan, Wang, Min-Fei
Format: Article
Language:English
Subjects:
Adult
Aged
Analgesics, Opioid - pharmacology
Brief Reports
Cell Movement - drug effects
Cell Movement - physiology
Cholecystectomy
Common Bile Duct Diseases - physiopathology
Common Bile Duct Diseases - surgery
Female
Humans
Male
Middle Aged
Muscle Contraction - drug effects
Muscle, Smooth
Pressure
Sphincter of Oddi - drug effects
Sphincter of Oddi - physiopathology
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Summary:To assess the effects of intramuscular analgesics (morphine, Ap-237, pethidine and tramadol) on human Oddi's sphincter motility with choledochoscope manometry. A total of 70 patients having T tubes after cholecystectomy and choledochotomy were assessed by choledochoscope manometry. They were randomly divided into morphine group, Ap-237 group, pethidine group and tramadol group. Basal pressure of Oddi's sphincter (BPOS), amplitude of phasic contractions (SOCA), frequency of phasic contractions (SOF), duration of phasic contractions(SOD), duodenal pressure (DP) and common bile duct pressure (CBDP) were scored and analyzed. All narcotic analgesic drugs were administered intramuscularly. Levels of BPOS, SOCA and SOF were increased after injection of morphine and Ap-237 (P
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v10.i19.2901