Mast cells in meningiomas and brain inflammation

Research focus in neuro-oncology has shifted in the last decades towards the exploration of tumor infiltration by a variety of immune cells and their products. T cells, macrophages, B cells, and mast cells (MCs) have been identified. A systematic review of the literature was conducted by searching P...

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Bibliographic Details
Published in:Journal of neuroinflammation 2015-09, Vol.12 (1), p.170-170, Article 170
Main Authors: Polyzoidis, Stavros, Koletsa, Triantafyllia, Panagiotidou, Smaro, Ashkan, Keyoumars, Theoharides, Theoharis C
Format: Article
Language:English
Subjects:
Animals
B cells
Brain tumors
Care and treatment
Complications and side effects
Databases, Bibliographic - statistics & numerical data
Encephalitis - immunology
Encephalitis - pathology
Gliomas
Humans
Inflammation
Mast Cells - pathology
Meningeal Neoplasms - immunology
Meningeal Neoplasms - pathology
Meningioma - immunology
Meningioma - pathology
Metastasis
Review
Risk factors
T cells
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Summary:Research focus in neuro-oncology has shifted in the last decades towards the exploration of tumor infiltration by a variety of immune cells and their products. T cells, macrophages, B cells, and mast cells (MCs) have been identified. A systematic review of the literature was conducted by searching PubMed, EMBASE, Google Scholar, and Turning Research into Practice (TRIP) for the presence of MCs in meningiomas using the terms meningioma, inflammation and mast cells. MCs have been detected in various tumors of the central nervous system (CNS), such as gliomas, including glioblastoma multiforme, hemangioblastomas, and meningiomas as well as metastatic brain tumors. MCs were present in as many as 90 % of all high-grade meningiomas mainly found in the perivascular areas of the tumor. A correlation between peritumoral edema and MCs was found. Accumulation of MCs in meningiomas could contribute to the aggressiveness of tumors and to brain inflammation that may be involved in the pathogenesis of additional disorders.
ISSN:1742-2094
1742-2094
DOI:10.1186/s12974-015-0388-3