Systematic synergy modeling: understanding drug synergy from a systems biology perspective

Owing to drug synergy effects, drug combinations have become a new trend in combating complex diseases like cancer, HIV and cardiovascular diseases. However, conventional synergy quantification methods often depend on experimental dose-response data which are quite resource-demanding. In addition, t...

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Bibliographic Details
Published in:BMC systems biology 2015-09, Vol.9 (1), p.56-56, Article 56
Main Authors: Chen, Di, Liu, Xi, Yang, Yiping, Yang, Hongjun, Lu, Peng
Format: Article
Language:English
Subjects:
Cardiovascular diseases
Care and treatment
Complications and side effects
Development and progression
Drug Synergism
Drug therapy, Combination
Humans
Models, Biological
Protein Interaction Mapping
Protein-protein interactions
Review
Risk factors
Systems Biology - methods
Type 2 diabetes
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Summary:Owing to drug synergy effects, drug combinations have become a new trend in combating complex diseases like cancer, HIV and cardiovascular diseases. However, conventional synergy quantification methods often depend on experimental dose-response data which are quite resource-demanding. In addition, these methods are unable to interpret the explicit synergy mechanism. In this review, we give representative examples of how systems biology modeling offers strategies toward better understanding of drug synergy, including the protein-protein interaction (PPI) network-based methods, pathway dynamic simulations, synergy network motif recognitions, integrative drug feature calculations, and "omic"-supported analyses. Although partially successful in drug synergy exploration and interpretation, more efforts should be put on a holistic understanding of drug-disease interactions, considering integrative pharmacology and toxicology factors. With a comprehensive and deep insight into the mechanism of drug synergy, systems biology opens a novel avenue for rational design of effective drug combinations.
ISSN:1752-0509
1752-0509
DOI:10.1186/s12918-015-0202-y