Successful Treatment of Carbapenemase-Producing Pandrug-Resistant Klebsiella pneumoniae Bacteremia

New antibiotic options are urgently needed for the treatment of carbapenem-resistant Enterobacteriaceae infections. We report a 64-year-old female with prolonged hospitalization following an intestinal transplant who developed refractory bacteremia due to a serine carbapenemase-producing pandrug-res...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2015-10, Vol.59 (10), p.5903-5908
Main Authors: Camargo, Jose F, Simkins, Jacques, Beduschi, Thiago, Tekin, Akin, Aragon, Laura, Pérez-Cardona, Armando, Prado, Clara E, Morris, Michele I, Abbo, Lilian M, Cantón, Rafael
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Anti-Bacterial Agents - therapeutic use
Antiviral Agents - therapeutic use
Azabicyclo Compounds - therapeutic use
Bacteremia
Bacteremia - drug therapy
Bacteremia - microbiology
Bacteremia - pathology
Bacterial Proteins
Bacterial Proteins - biosynthesis
beta-Lactamases
beta-Lactamases - biosynthesis
Carbapenems - therapeutic use
Ceftazidime - therapeutic use
Challenging Clinical Case in Antimicrobial Resistance
Challenging Clinical Cases in Antimicrobial Resistance
Colectomy
Colistin - therapeutic use
Drug Resistance, Multiple, Bacterial
Female
Ganciclovir - analogs & derivatives
Ganciclovir - therapeutic use
Humans
Immunosuppressive Agents - therapeutic use
Intestine, Small
Intestine, Small - drug effects
Intestine, Small - microbiology
Intestine, Small - transplantation
Klebsiella Infections
Klebsiella Infections - drug therapy
Klebsiella Infections - microbiology
Klebsiella Infections - pathology
Klebsiella pneumoniae
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - enzymology
Klebsiella pneumoniae - growth & development
Microbial Sensitivity Tests
Middle Aged
Minocycline - analogs & derivatives
Minocycline - therapeutic use
Thienamycins - therapeutic use
Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use
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Summary:New antibiotic options are urgently needed for the treatment of carbapenem-resistant Enterobacteriaceae infections. We report a 64-year-old female with prolonged hospitalization following an intestinal transplant who developed refractory bacteremia due to a serine carbapenemase-producing pandrug-resistant isolate of Klebsiella pneumoniae. After failing multiple antimicrobial regimens, the patient was successfully treated.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00655-15