Connexin36 expression in major centers of the auditory system in the CNS of mouse and rat: Evidence for neurons forming purely electrical synapses and morphologically mixed synapses

Highlights • Cx36 is widely expressed in the auditory system of rat and mouse. • Neuronal gap junctions composed of Cx36 are abundant in the auditory system. • Auditory nuclei contain nerve terminals forming morphologically mixed synapses. • Nerve terminals associated with Cx36 in the cochlear nucle...

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Bibliographic Details
Published in:Neuroscience 2015-09, Vol.303, p.604-629
Main Authors: Rubio, M.E, Nagy, J.I
Format: Article
Language:English
Subjects:
Animals
Auditory Pathways - cytology
Auditory Pathways - metabolism
Calbindin 1 - metabolism
Calyx of Held
Cochlear nucleus
Cochlear Nucleus - cytology
Cochlear Nucleus - metabolism
Connexin36
Connexins - genetics
Connexins - metabolism
Electric Stimulation
Electrical synapses
Electrical Synapses - metabolism
Electrical Synapses - ultrastructure
Functional Laterality - physiology
Gap Junction delta-2 Protein
Green Fluorescent Proteins - genetics
Green Fluorescent Proteins - metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microscopy, Electron, Transmission
Mixed chemical/electrical synapses
Neurology
Neuronal gap junctions
Neurons - metabolism
Rats
Rats, Sprague-Dawley
Superior Olivary Complex - cytology
Superior Olivary Complex - metabolism
Vesicular Glutamate Transport Protein 1 - metabolism
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Summary:Highlights • Cx36 is widely expressed in the auditory system of rat and mouse. • Neuronal gap junctions composed of Cx36 are abundant in the auditory system. • Auditory nuclei contain nerve terminals forming morphologically mixed synapses. • Nerve terminals associated with Cx36 in the cochlear nucleus are of primary afferent origin.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.07.026