Metformin as an anticancer drug: A Commentary on the metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

Metformin is widely used antidiabetic drug and also shows anticancer effect. As cancers arise more frequently in subjects with diabetes, knowledge on its effects on cancer metabolism might improve the treatment of diabetes.

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Bibliographic Details
Published in:Journal of diabetes investigation 2015-09, Vol.6 (5), p.516-518
Main Authors: Song, In‐Sung, Han, Jin, Lee, Hong Kyu
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Antidiabetics
Cancer
Cell growth
Commentaries
Diabetes mellitus
Energy metabolism
Glucose
Glycolysis
Inflammation
Kinases
Metformin
Mitochondria
Mitochondrial DNA
Pollutants
Tumors
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Description
Summary:Metformin is widely used antidiabetic drug and also shows anticancer effect. As cancers arise more frequently in subjects with diabetes, knowledge on its effects on cancer metabolism might improve the treatment of diabetes.
ISSN:2040-1116
2040-1124
DOI:10.1111/jdi.12300