Cytosolic BMAL1 moonlights as a translation factor

It is widely recognized that BMAL1 is an essential subunit of the primary transcription factor that drives rhythmic circadian transcription in the nucleus. In a surprising turn, Lipton et al. now show that BMAL1 rhythmically interacts with translational machinery in the cytosol to stimulate protein...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2015-09, Vol.40 (9), p.489-490
Main Authors: Michael, Alicia K., Asimgil, Hande, Partch, Carrie L.
Format: Article
Language:English
Subjects:
Animals
ARNTL Transcription Factors - metabolism
Circadian Clocks
cytosol
protein synthesis
Ribosomal Protein S6 Kinases, 90-kDa - metabolism
transcription factors
translation (genetics)
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Summary:It is widely recognized that BMAL1 is an essential subunit of the primary transcription factor that drives rhythmic circadian transcription in the nucleus. In a surprising turn, Lipton et al. now show that BMAL1 rhythmically interacts with translational machinery in the cytosol to stimulate protein synthesis in response to mTOR signaling.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2015.07.006