A single center clinical analysis of children with neuroblastoma

In the present study, the cases of 59 children diagnosed with neuroblastoma (NB) were retrospectively analyzed to assess the association between the short-term efficacy of treatment and prognostic factors. In total, 59 patients with NB that were diagnosed between July 1, 2008 and June 30, 2013 at Sh...

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Bibliographic Details
Published in:Oncology letters 2015-10, Vol.10 (4), p.2311-2318
Main Authors: SHAO, JING-BO, LU, ZHENG-HUA, HUANG, WEN-YAN, LV, ZHI-BAO, JIANG, HUI
Format: Article
Language:English
Subjects:
Abdomen
Age
Bone marrow
Chemotherapy
children
Children & youth
Classification
efficacy
Hematology
Histology
Histopathology
Medical imaging
Medical prognosis
Metastasis
Mortality
Neuroblastoma
Oncology
Pathology
Patients
prognosis
Software
Ultrasonic imaging
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Summary:In the present study, the cases of 59 children diagnosed with neuroblastoma (NB) were retrospectively analyzed to assess the association between the short-term efficacy of treatment and prognostic factors. In total, 59 patients with NB that were diagnosed between July 1, 2008 and June 30, 2013 at Shanghai Children's Hospital were enrolled in the present study. The follow-up was performed until December 31, 2013, and the data revealed that 43 patients (72.9%) achieved complete remission (CR) or partial remission (PR). The 3-year overall survival (OS) rate of patients with stage I, II, III, IV and IVs disease was 100, 100, 65.6, 34.8 and 85.7%, respectively (P=0.02). The 3-year OS and event-free survival rates were evidently increased in patients with favorable histology compared with the rates in the patients with unfavorable histology (P=0.046 and 0.030, respectively). Univariate statistical analysis revealed that the factors significantly associated with prognosis were patient age, tumor stage and risk group (P=0.004, 0.02 and 0.001, respectively). The present study identified that tumor stage, risk group and patient age are important prognostic factors for NB. An age of 18 months was also hypothesized to be the cut-off for the prognosis of patients.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2015.3588