Establishment of a Zebrafish Infection Model for the Study of Wild-Type and Recombinant European Sheatfish Virus

Amphibian-like ranaviruses include pathogens of fish, amphibians, and reptiles that have recently evolved from a fish-infecting ancestor. The molecular determinants of host range and virulence in this group are largely unknown, and currently fish infection models are lacking. We show that European s...

Full description

Saved in:
Bibliographic Details
Published in:Journal of virology 2015-10, Vol.89 (20), p.10702-10706
Main Authors: Martín, Verónica, Mavian, Carla, López Bueno, Alberto, de Molina, Antonio, Díaz, Eduardo, Andrés, Germán, Alcami, Antonio, Alejo, Alí
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Danio rerio
Disease Models, Animal
DNA Virus Infections - pathology
DNA Virus Infections - veterinary
DNA Virus Infections - virology
Fish Diseases - pathology
Fish Diseases - virology
Freshwater
Genetic Engineering
Genotype
Larva - virology
Molecular Sequence Data
Pathogenesis and Immunity
Phylogeny
Ranavirus
Ranavirus - classification
Ranavirus - genetics
Ranavirus - pathogenicity
Virulence
Zebrafish - virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Amphibian-like ranaviruses include pathogens of fish, amphibians, and reptiles that have recently evolved from a fish-infecting ancestor. The molecular determinants of host range and virulence in this group are largely unknown, and currently fish infection models are lacking. We show that European sheatfish virus (ESV) can productively infect zebrafish, causing a lethal pathology, and describe a method for the generation of recombinant ESV, establishing a useful model for the study of fish ranavirus infections.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.01580-15