Long noncoding RNA expression profiles of the doxorubicin-resistant human osteosarcoma cell line MG63/DXR and its parental cell line MG63 as ascertained by microarray analysis

Long non-coding RNAs (lncRNAs) are emerging in molecular biology as crucial regulators of cancer. The efficacy of doxorubicin--based chemotherapy in osteosarcoma (OS) is usually limited by acquired drug resistance. To explore the mechanism of chemoresistance of OS in terms of lncRNA, using a human l...

Full description

Saved in:
Bibliographic Details
Published in:International journal of clinical and experimental pathology 2015-01, Vol.8 (8), p.8754-8773
Main Authors: Zhu, Kun-Peng, Zhang, Chun-Lin, Shen, Guo-Qi, Zhu, Zhong-Sheng
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antineoplastic Agents - therapeutic use
Bone Neoplasms - drug therapy
Bone Neoplasms - genetics
Bone Neoplasms - mortality
Cell Line, Tumor
Child
Doxorubicin - therapeutic use
Drug Resistance, Neoplasm - genetics
Female
Gene Expression Profiling - methods
Humans
Kaplan-Meier Estimate
Male
Oligonucleotide Array Sequence Analysis
Original
Osteosarcoma - drug therapy
Osteosarcoma - genetics
Osteosarcoma - mortality
Polymerase Chain Reaction
RNA, Long Noncoding - genetics
Transcriptome
Young Adult
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Long non-coding RNAs (lncRNAs) are emerging in molecular biology as crucial regulators of cancer. The efficacy of doxorubicin--based chemotherapy in osteosarcoma (OS) is usually limited by acquired drug resistance. To explore the mechanism of chemoresistance of OS in terms of lncRNA, using a human lncRNA-mRNA combined microarray, we identified 3,465 lncRNAs (1,761 up and 1,704 down) and 3,278 mRNAs (1,607 up and 1,671 down) aberrantly expressed in all three sets of doxorubicin-resistant MG63/DXR and their paired parental MG63 cells (fold-change >2.0, P
ISSN:1936-2625