Functional role of regulatory T cells in B cell lymphoma and related mechanisms

B cell lymphoma (BCL) has a higher degree of malignancy and complicated pathogenic mechanism. Regulatory T cells (Treg cells) are known to exert certain immune suppression functions, in addition to immune mediating effects. Recent studies have revealed the role of Treg cells in pathogenesis and prog...

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Bibliographic Details
Published in:International journal of clinical and experimental pathology 2015-01, Vol.8 (8), p.9133-9139
Main Authors: Wu, Wei, Wan, Jun, Xia, Ruixiang, Huang, Zhenqi, Ni, Jing, Yang, Mingzhen
Format: Article
Language:English
Subjects:
Adolescent
Adult
Female
Forkhead Transcription Factors - metabolism
Humans
Interleukin-10 - metabolism
Lymphoma, B-Cell - immunology
Lymphoma, B-Cell - metabolism
Lymphoma, B-Cell - pathology
Male
Middle Aged
Original
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
T-Lymphocytes, Regulatory - pathology
Transforming Growth Factor beta1 - metabolism
Young Adult
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Summary:B cell lymphoma (BCL) has a higher degree of malignancy and complicated pathogenic mechanism. Regulatory T cells (Treg cells) are known to exert certain immune suppression functions, in addition to immune mediating effects. Recent studies have revealed the role of Treg cells in pathogenesis and progression of multiple malignant tumors. This study therefore investigated the functional role and related mechanism of Treg cells in BCL. A cohort of thirty patients who were diagnosed with BCL in our hospital between January 2013 and December 2014. Another thirty healthy individuals were recruited. Peripheral blood mononuclear cells (PBMCs) were separated and analyzed for the ratio of CD4+/CD25+ Treg cells. The mRNA expression levels of Foxp3, transforming growth factor (TGF)-β1 and interleukin (IL)-10 genes were quantified by real-time PCR, while their serum levels were determined by enzyme-linked immunosorbent assay (ELISA). Meanwhile all laboratory indexes for patients were monitored during the complete remission (CR) stage. BCL patients significantly elevated ratio of CD4+/CD25+ Treg cells, which were decreased at CR stage. mRNA levels of Foxp3, TGF-β1 and IL-10, in addition to protein levels of TGF-β1 and IL-10 were potentiated in lymphoma patients but decreased in CR patients (P
ISSN:1936-2625