Associations between interleukin and interleukin receptor gene polymorphisms and risk of gout

• Published in: Scientific reports 2015-09, Vol.5 (1), p.13887-13887, Article 13887
• Main Authors: Liu, Shiguo, Zhou, Zheng, Wang, Can, Guo, Mingzhen, Chu, Nan, Li, Changgui
• Format: Article
• Language: English
• Subjects: 631/208/727/2000; 631/250/256/2516; Adult; Alleles; Arthritis; Case-Control Studies; Crystals; Cytokines; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Gout; Gout - epidemiology; Gout - genetics; Humanities and Social Sciences; Humans; Inflammation; Interleukin 1 receptors; Interleukins - genetics; Male; Middle Aged; Minority & ethnic groups; multidisciplinary; Polymerase chain reaction; Polymorphism, Single Nucleotide; Receptors, Interleukin - genetics; Risk; Science; Science (multidisciplinary); Stat4 protein; Studies; Synovial fluid; Transcription; Uric acid
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep13887

Gout is a self-limiting, auto-inflammatory arthritis induced by the deposition of monosodium urate crystals in the synovial fluid and periarticular tissues. The aim of this study was to investigate the associations between genetic variants in the interleukin (IL) and interleukin receptor (ILR) genes IL-33 , IL-1RL1 , IL-23R and signal transducer and activator of transcription 4 ( STAT4 ) and susceptibility to gout in Chinese Han male individuals. The genetic distributions of rs3939286 in IL-33 , rs13015714 in IL-1RL1 , rs10889677 in IL-23R and rs7574865 in STAT4 were detected in 1100 men with gout and 1227 ethnically matched controls, using Taqman allelic discrimination real-time polymerase chain reaction (PCR). Differences in these polymorphisms between the groups were investigated using χ 2 tests. The genotype-phenotype relationship among gout patients was tested by analysis of variance. There was a significant difference in genotypic frequencies of IL-23R rs10889677 between gout patients and controls (χ 2  = 81.386, P