Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy

Left ventricular hypertrophy (LVH) is a common complication in patients with CKD and an independent risk factor for death. Changes in the levels of uremic solutes or Klotho have been reported to be related to CKD, whereas the relationships between these factors and CKD-associated LVH remain unclear....

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Bibliographic Details
Published in:Journal of the American Society of Nephrology 2015-10, Vol.26 (10), p.2434-2446
Main Authors: Yang, Ke, Wang, Cheng, Nie, Ling, Zhao, Xiaohui, Gu, Jun, Guan, Xu, Wang, Song, Xiao, Tangli, Xu, Xinli, He, Ting, Xia, Xuefeng, Wang, Junping, Zhao, Jinghong
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Basic Research
Female
Glucuronidase - blood
Glucuronidase - physiology
Glucuronidase - therapeutic use
Humans
Hypertrophy, Left Ventricular - blood
Hypertrophy, Left Ventricular - chemically induced
Hypertrophy, Left Ventricular - etiology
Hypertrophy, Left Ventricular - prevention & control
Indican - administration & dosage
Indican - blood
Indican - physiology
Male
Mice
Mice, Inbred C57BL
Middle Aged
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - complications
Young Adult
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Summary:Left ventricular hypertrophy (LVH) is a common complication in patients with CKD and an independent risk factor for death. Changes in the levels of uremic solutes or Klotho have been reported to be related to CKD, whereas the relationships between these factors and CKD-associated LVH remain unclear. Here, we investigated the interaction between Klotho and indoxyl sulfate (IS), a typical uremic solute, in CKD-associated LVH. In a survey of 86 patients with CKD, a negative relationship was found between serum levels of IS and Klotho (r=-0.59, P
ISSN:1046-6673
1533-3450
DOI:10.1681/ASN.2014060543