Down-regulated microRNA-124 expression as predictive biomarker and its prognostic significance with clinicopathological features in breast cancer patients

MicroRNAs (miRNAs) have been documented as playing important roles in cancer development. In this study, we investigated to clarify the clinicopathological significance and prognostic value of miR-124 in breast cancer. Quantitative Real-time PCR method was used to assess the expression levels of miR...

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Bibliographic Details
Published in:Diagnostic pathology 2015-09, Vol.10, p.178-178
Main Authors: Arabkheradmand, Ali, Safari, Aghdas, Seifoleslami, Mehri, Yahaghi, Emad, Gity, Masoumeh
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cancer
Cancer patients
Care and treatment
Development and progression
Down-Regulation
Female
Gene Expression Regulation, Neoplastic - genetics
Genetic aspects
Health aspects
Humans
Lymphatic Metastasis - pathology
Metastasis
MicroRNA
MicroRNAs - metabolism
Middle Aged
Oncology, Experimental
Patient outcomes
Prognosis
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Summary:MicroRNAs (miRNAs) have been documented as playing important roles in cancer development. In this study, we investigated to clarify the clinicopathological significance and prognostic value of miR-124 in breast cancer. Quantitative Real-time PCR method was used to assess the expression levels of miR-124 in breast cancer patients and the association of miR-124 expression levels with the clinicopathological characteristics in breast cancer patients. Survival and Multivariate Cox proportional hazards model analysis was used to evaluate whether the miR-124 expression level and various clinicopathological characteristics were independent prognostic marker for breast cancer patients. We found that the lower expression of miR-124 in breast cancer specimens compared with corresponding adjacent normal breast tissues P 
ISSN:1746-1596
1746-1596
DOI:10.1186/s13000-015-0391-0