JBP485 promotes corneal epithelial wound healing

Proper wound healing is vital for maintenance of corneal integrity and transparency. Corneal epithelial damage is one of the most frequently observed ocular disorders. Because clinical options are limited, further novel treatments are needed to improve clinical outcomes for this type of disease. In...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2015-10, Vol.5 (1), p.14776-14776, Article 14776
Main Authors: Nagata, Maho, Nakamura, Takahiro, Hata, Yuiko, Yamaguchi, Shumpei, Kaku, Taiichi, Kinoshita, Shigeru
Format: Article
Language:English
Subjects:
13/106
13/51
14/19
631/61/490
631/80/83/2359
631/80/84
Animals
Cell Movement - drug effects
Cell proliferation
Cell Proliferation - drug effects
Cell Survival - drug effects
Cells, Cultured
Cornea
Epithelial cells
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Epithelium, Corneal - drug effects
Epithelium, Corneal - pathology
Eye diseases
Eye disorders
Humanities and Social Sciences
multidisciplinary
Peptides, Cyclic - pharmacology
Placenta
Rabbits
Science
Vascularization
Wound healing
Wound Healing - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Proper wound healing is vital for maintenance of corneal integrity and transparency. Corneal epithelial damage is one of the most frequently observed ocular disorders. Because clinical options are limited, further novel treatments are needed to improve clinical outcomes for this type of disease. In the present study, it was found that placental extract-derived dipeptide (JBP485) significantly increased the proliferation and migration of corneal epithelial cells (CECs). Moreover, JBP485 accelerated corneal epithelial wound healing in vivo without inflammation and neovascularization and was found to be effective for the treatment of corneal damage. These data indicate that JBP485 efficiently activates the viability of CECs and has potential as a novel treatment for various kinds of corneal epithelial disease.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep14776