Anti-tumor activity of lipophilic imidazolium salts on select NSCLC cell lines

The anti-tumor activity of imidazolium salts is highly dependent upon the substituents on the nitrogen atoms of the imidazolium cation. We have synthesized and characterized a series of naphthalene-substituted imidazolium salts and tested them against a variety of non-small-cell lung cancer cell lin...

Full description

Saved in:
Bibliographic Details
Published in:Medicinal chemistry research 2015-07, Vol.24 (7), p.2838-2861
Main Authors: Wright, Brian D., Deblock, Michael C., Wagers, Patrick O., Duah, Ernest, Robishaw, Nikki K., Shelton, Kerri L., Southerland, Marie R., DeBord, Michael A., Kersten, Kortney M., McDonald, Lucas J., Stiel, Jason A., Panzner, Matthew J., Tessier, Claire A., Paruchuri, Sailaja, Youngs, Wiley J.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The anti-tumor activity of imidazolium salts is highly dependent upon the substituents on the nitrogen atoms of the imidazolium cation. We have synthesized and characterized a series of naphthalene-substituted imidazolium salts and tested them against a variety of non-small-cell lung cancer cell lines. Several of these complexes displayed anticancer activity comparable to cisplatin. These compounds induced apoptosis in the NCI-H460 cell line as determined by Annexin V staining, caspase-3, and PARP cleavage. These results strongly suggest that this class of compounds can serve as potent chemotherapeutic agents. Graphical Abstract
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-015-1330-z