GATA family transcriptional factors: emerging suspects in hematologic disorders

GATA transcription factors are zinc finger DNA binding proteins that regulate transcription during development and cell differentiation. The three important GATA transcription factors GATA1, GATA2 and GATA3 play essential roles in the development and maintenance of hematopoietic systems. GATA1 is re...

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Bibliographic Details
Published in:Experimental hematology & oncology 2015-10, Vol.4 (1), p.28-28, Article 28
Main Authors: Gao, Juehua, Chen, Yi-Hua, Peterson, LoAnn C
Format: Article
Language:English
Subjects:
Anemia
Blood diseases
Bone marrow
Cell cycle
Cell differentiation
Deoxyribonucleic acid
DNA
DNA binding proteins
Down syndrome
Epigenetics
Gene expression
Genetic aspects
Genetic transcription
Granulocytes
Health aspects
Leukemia
Lymphoma
Mutation
Protein binding
Protein expression
Proteins
Review
Rodents
Stem cells
Transcription factors
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Summary:GATA transcription factors are zinc finger DNA binding proteins that regulate transcription during development and cell differentiation. The three important GATA transcription factors GATA1, GATA2 and GATA3 play essential roles in the development and maintenance of hematopoietic systems. GATA1 is required for the erythroid and megakaryocytic commitment during hematopoiesis. GATA2 is crucial for the proliferation and survival of early hematopoietic cells, and is also involved in lineage specific transcriptional regulation as the dynamic partner of GATA1. GATA3 plays an essential role in T lymphoid cell development and immune regulation. As a result, mutations in genes encoding the GATA transcription factors or alteration in the protein expression level or their function have been linked to a variety of human hematologic disorders. In this review, we summarized the current knowledge regarding the disrupted biologic function of GATA in various hematologic disorders.
ISSN:2162-3619
2162-3619
DOI:10.1186/s40164-015-0024-z