Reported co-infection deaths are more common in early adulthood and among similar infections

• Published in: BMC infectious diseases 2015-10, Vol.15 (1), p.411, Article 411
• Main Authors: Griffiths, E C, Pedersen, A B, Fenton, A, Petchey, O L
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Analysis; Care and treatment; Cause of Death; Child; Child, Preschool; Coinfection - mortality; Complications and side effects; Disease transmission; England - epidemiology; Female; Health aspects; Humans; Infant; Infant, Newborn; Infectious diseases; Male; Medical research; Medicine, Experimental; Middle Aged; Mortality; Risk factors; United Kingdom; United States - epidemiology; Wales - epidemiology; Young Adult
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-015-1118-2

Many people have multiple infections at the same time, but the combined contribution of those infections to disease-related mortality is unknown. Registered causes of death offer a unique opportunity to study associations between multiple infections. We analysed over 900,000 death certificates that reported infectious causes of death. We tested whether reports of multiple infections (i.e., co-infections) differed across individuals' age or sex. We also tested whether each pair of infections were reported together more or less often than expected by chance, and whether this co-reporting was associated with the number of biological characteristics they had in common. In England and Wales, and the USA, 10 and 6 % respectively of infection-related deaths involved co-infection. Co-infection was reported reported most often in young adults; 30 % of infection-related deaths among those aged 25-44 from the USA, and 20 % of infection-related deaths among those aged 30-39 from England and Wales, reported multiple infections. The proportion of infection-related deaths involving co-infection declined with age more slowly in males than females, to less than 10 % among those aged >65. Most associated pairs of infections co-occurred more often than expected from their frequency of being reported alone (488/683 [71 %] in the USA, 129/233 [55 %] in England and Wales), and tended to share biological characteristics (taxonomy, transmission mode, tropism or timescale). Age, sex, and biologically similar infections are associated with death from co-infection, and may help indicate patients at risk of severe co-infection.