A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans

Brown adipose tissue (BAT) has been proposed as a potential target tissue against obesity and its related metabolic complications. Although the molecular and functional characteristics of BAT have been intensively studied in rodents, only a few studies have used human BAT specimens due to the diffic...

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Bibliographic Details
Published in:International Journal of Obesity 2015-10, Vol.39 (10), p.1561-1564
Main Authors: Chondronikola, M, Annamalai, P, Chao, T, Porter, C, Saraf, M K, Cesani, F, Sidossis, L S
Format: Article
Language:English
Subjects:
13/51
631/443/319/2723
692/699/2743/393
692/700/139/1420
Adipose tissue
Adipose tissue (brown)
Adipose Tissue, Brown - pathology
Adipose tissues
Adult
Biopsy
Biopsy, Fine-Needle - methods
Biopsy, Needle
Body fat
Clavicle
Cold Temperature
Computed tomography
Epidemiology
Health Promotion and Disease Prevention
Hematoma
Humans
Internal Medicine
Male
Medical imaging
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Obesity
Obesity - metabolism
Obesity - pathology
Positron emission
Positron emission tomography
Preventive medicine
Public Health
Sampling
short-communication
Suctioning
Thermogenesis
Tomography
Tomography, X-Ray Computed
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Description
Summary:Brown adipose tissue (BAT) has been proposed as a potential target tissue against obesity and its related metabolic complications. Although the molecular and functional characteristics of BAT have been intensively studied in rodents, only a few studies have used human BAT specimens due to the difficulty of sampling human BAT deposits. We established a novel positron emission tomography and computed tomography-guided Bergström needle biopsy technique to acquire human BAT specimens from the supraclavicular area in human subjects. Forty-three biopsies were performed on 23 participants. The procedure was tolerated well by the majority of participants. No major complications were noted. Numbness (9.6%) and hematoma (2.3%) were the two minor complications noted, which fully resolved. Thus, the proposed biopsy technique can be considered safe with only minimal risk of adverse events. Adoption of the proposed method is expected to increase the sampling of the supraclavicular BAT depot for research purposes so as to augment the scientific knowledge of the biology of human BAT.
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2015.76