ProPepper: a curated database for identification and analysis of peptide and immune-responsive epitope composition of cereal grain protein families

ProPepper is a database that contains prolamin proteins identified from true grasses (Poaceae), their peptides obtained with single- and multi-enzyme in silico digestions as well as linear T- and B-cell-specific epitopes that are responsible for wheat-related food disorders. The integrated database...

Full description

Saved in:
Bibliographic Details
Published in:Database : the journal of biological databases and curation 2015, Vol.2015
Main Authors: Juhász, Angéla, Haraszi, Réka, Maulis, Csaba
Format: Article
Language:English
Subjects:
Animals
Databases, Protein
Edible Grain - chemistry
Edible Grain - genetics
Edible Grain - immunology
Epitopes, B-Lymphocyte - chemistry
Epitopes, B-Lymphocyte - genetics
Epitopes, B-Lymphocyte - immunology
Epitopes, T-Lymphocyte - chemistry
Epitopes, T-Lymphocyte - genetics
Epitopes, T-Lymphocyte - immunology
Humans
Original
Peptides
Plant Proteins - chemistry
Plant Proteins - genetics
Plant Proteins - immunology
Poaceae - chemistry
Poaceae - genetics
Poaceae - metabolism
Proteins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ProPepper is a database that contains prolamin proteins identified from true grasses (Poaceae), their peptides obtained with single- and multi-enzyme in silico digestions as well as linear T- and B-cell-specific epitopes that are responsible for wheat-related food disorders. The integrated database and analysis platform contains datasets that are collected from multiple public databases (UniprotKB, IEDB, NCBI GenBank), manually curated and annotated, and interpreted in three main data tables: Protein-, Peptide- and Epitope list views that are cross-connected by unique identifications. Altogether 21 genera and 80 different species are represented. Currently, the database contains 2146 unique and complete protein sequences related to 2618 GenBank entries and 35 657 unique peptide sequences that are a result of 575 110 unique digestion events obtained by in silico digestion methods involving six proteolytic enzymes and their combinations. The interface allows advanced global and parametric search functions along with a download option, with direct connections to the relevant public databases. Database URL: https://propepper.net.
ISSN:1758-0463
1758-0463
DOI:10.1093/database/bav100