Inflammation decreases keratin level in ulcerative colitis; inadequate restoration associates with increased risk of colitis-associated cancer

BackgroundKeratins are intermediate filament (IF) proteins, which form part of the epithelial cytoskeleton and which have been implicated pathology of inflammatory bowel diseases (IBD).MethodsIn this study biopsies were obtained from IBD patients grouped by disease duration and subtype into eight ca...

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Bibliographic Details
Published in:BMJ open gastroenterology 2015, Vol.2 (1), p.e000024-e000024
Main Authors: Corfe, Bernard M, Majumdar, Debabrata, Assadsangabi, Arash, Marsh, Alexandra M R, Cross, Simon S, Connolly, Joanne B, Evans, Caroline A, Lobo, Alan J
Format: Article
Language:English
Subjects:
Apoptosis
Colorectal cancer
Cytoskeleton
Endoscopy
Gastroenterology
Inflammation
Inflammatory Bowel Disease
Keratin
Kinases
Mutation
Pancreatic cancer
Pathogenesis
Phosphorylation
Proteins
Proteomics
Tumor necrosis factor-TNF
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Summary:BackgroundKeratins are intermediate filament (IF) proteins, which form part of the epithelial cytoskeleton and which have been implicated pathology of inflammatory bowel diseases (IBD).MethodsIn this study biopsies were obtained from IBD patients grouped by disease duration and subtype into eight categories based on cancer risk and inflammatory status: quiescent recent onset (
ISSN:2054-4774
2054-4774
DOI:10.1136/bmjgast-2014-000024