Amiodarone pneumonitis: three further cases with a review of published reports

The authors read with interest the paper by Dr. J.I. Darmanata and his colleagues describing three new cases of amiodarone induced pneumonitis and reviewing 32 other reported cases. The authors conclude that proof of an underlying immunological process is lacking. Even if in the majority of cases th...

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Bibliographic Details
Published in:Thorax 1984-10, Vol.39 (10), p.800-800
Main Authors: Akoun, G M, Gauthier-Rahman, S
Format: Article
Language:English
Subjects:
Alveolitis, Extrinsic Allergic - chemically induced
Amiodarone - adverse effects
Benzofurans - adverse effects
Drug Hypersensitivity - etiology
Humans
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Summary:The authors read with interest the paper by Dr. J.I. Darmanata and his colleagues describing three new cases of amiodarone induced pneumonitis and reviewing 32 other reported cases. The authors conclude that proof of an underlying immunological process is lacking. Even if in the majority of cases the mechanism of the disease appears to be a purely toxic one, it seems possible that an immunological process may be involved in others. These arguments suggest that in some cases at least an immunological mechanism-cell mediated hypersensitivity-is the originator of amiodarone pneumonitis.
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.39.10.800