Inflammation induced loss of skeletal muscle

Abstract Inflammation is an important contributor to the pathology of diseases implicated in skeletal muscle dysfunction. A number of diseases and disorders including inflammatory myopathies and Chronic Obstructive Pulmonary Disorder (COPD) are characterized by chronic inflammation or elevation of t...

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Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2015-11, Vol.80, p.131-142
Main Authors: Londhe, Priya, Guttridge, Denis C
Format: Article
Language:English
Subjects:
Animals
Atrophy
Cytokines
Cytokines - metabolism
Differentiation
Humans
Inflammation
Inflammation - immunology
Inflammation - metabolism
Muscle
Muscle, Skeletal - immunology
Muscle, Skeletal - metabolism
Muscular Atrophy - immunology
Muscular Atrophy - metabolism
Orthopedics
Skeletal
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Summary:Abstract Inflammation is an important contributor to the pathology of diseases implicated in skeletal muscle dysfunction. A number of diseases and disorders including inflammatory myopathies and Chronic Obstructive Pulmonary Disorder (COPD) are characterized by chronic inflammation or elevation of the inflammatory mediators. While these disease states exhibit different pathologies, all have in common the loss of skeletal muscle mass and a deregulated skeletal muscle physiology. Pro-inflammatory cytokines are key contributors to chronic inflammation found in many of these diseases. This section of the review focuses on some of the known inflammatory disorders like COPD, Rheumatoid Arthritis (RA) and inflammatory myopathies that display skeletal muscle atrophy and also provides the reader an overview of the mediators of inflammation, their signaling pathways, and mechanisms of action. This article is part of a Special Issue entitled "Muscle Bone Interactions".
ISSN:8756-3282
1873-2763
DOI:10.1016/j.bone.2015.03.015